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. 2015 Apr 15;137(14):4666-9.
doi: 10.1021/jacs.5b02316. Epub 2015 Apr 6.

Highly diastereo- and enantioselective CuH-catalyzed synthesis of 2,3-disubstituted indolines

Erhad Ascic  1 , Stephen L Buchwald  1
Affiliations

Highly diastereo- and enantioselective CuH-catalyzed synthesis of 2,3-disubstituted indolines

Erhad Ascic et al. J Am Chem Soc. .

Abstract

A diastereo- and enantioselective CuH-catalyzed method for the preparation of highly functionalized indolines is reported. The mild reaction conditions and high degree of functional group compatibility as demonstrated with substrates bearing heterocycles, olefins, and substituted aromatic groups, renders this technique highly valuable for the synthesis of a variety of cis-2,3-disubstituted indolines in high yield and enantioeselectivity.

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Figures

Figure 1
Figure 1
Proposed catalytic cycle for CuH-catalyzed synthesis of 2,3-disubstituted indolines.
See this image and copyright information in PMC

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