doi: 10.1080/15476286.2015.1017232.
Mutual interaction between BCL6 and microRNAs in T cell differentiation
Affiliations
- PMID: 25826411
- PMCID: PMC4615890
- DOI: 10.1080/15476286.2015.1017232
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Mutual interaction between BCL6 and microRNAs in T cell differentiation
RNA Biol.
2015.
Abstract
The transcription factor B-cell CLL/lymphoma 6 (BCL6) and the regulatory factor microRNAs (miRNAs) are of great importance in the differentiation of T cell subsets. An increasing body of evidence has demonstrated that BCL6 and miRNAs can target one another and mutually adjust their expression in T cell subsets, such as T helper (Th)-2, Th17, CD8+ regulatory T (CD8+Treg) and T follicular helper (Tfh) cells. Here, we discuss the most recent advances and emerging concepts in how BCL6 and miRNAs regulate one another, and the effects of such mutual regulations on T cell subset differentiation.
Keywords: BCL6; T lymphocyte; differentiation; interaction; miRNA.
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