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Review
. 2015 Mar 27;20(4):5528-53.
doi: 10.3390/molecules20045528.

Tetrazolium compounds: synthesis and applications in medicine

Cheng-Xi Wei  1 , Ming Bian  2 , Guo-Hua Gong  3   4
Affiliations
Review

Tetrazolium compounds: synthesis and applications in medicine

Cheng-Xi Wei et al. Molecules. .

Abstract

Tetrazoles represent a class of five-membered heterocyclic compounds with polynitrogen electron-rich planar structural features. This special structure makes tetrazole derivatives useful drugs, explosives, and other functional materials with a wide range of applications in many fields of medicine, agriculture, material science, etc. Based on our research works on azoles and other references in recent years, this review covers reported work on the synthesis and biological activities of tetrazole derivatives.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structures of the regioisomeric tetrazole rings.
Scheme 1
Scheme 1
Synthesized route 1 for tetrazoles.
Scheme 2
Scheme 2
Synthesized route 2 for tetrazoles.
Scheme 3
Scheme 3
Synthesized route 3 for tetrazoles.
Scheme 4
Scheme 4
The most efficient route for synthesis of 2,5-disubstituted-tetrazoles.
Scheme 5
Scheme 5
Synthesized routes for compounds 18–22.
Figure 2
Figure 2
Structures of compounds 23–26.
Figure 3
Figure 3
Structures of compounds 27–32.
Figure 4
Figure 4
Structures of compounds 33–37.
Figure 5
Figure 5
Structures of compounds 38–45.
Figure 6
Figure 6
Structures of compounds 46–48.
Figure 7
Figure 7
Structures of compounds 49–52.
Figure 8
Figure 8
Structures of compounds 53–59.
Figure 9
Figure 9
Structures of compounds 60–66.
Figure 10
Figure 10
Structures of compounds 67–69.
Figure 11
Figure 11
Structures of compounds 70–73.
Figure 12
Figure 12
Structures of compounds 74–79.
Figure 13
Figure 13
Structures of compounds 80–82.
Figure 14
Figure 14
Structures of compounds 83–85.
Figure 15
Figure 15
Structure of compound 86.
Figure 16
Figure 16
Structures of compounds 87–93.
Figure 17
Figure 17
Structures of compounds 94–99.
Figure 18
Figure 18
Structures of compounds 100–102.
Figure 19
Figure 19
Structures of compounds 105–107.
Figure 20
Figure 20
Structures of compounds 108–112.
Figure 21
Figure 21
Structures of compounds 113–117.
Figure 22
Figure 22
Structures of compounds 118–122.
Figure 23
Figure 23
Structures of compounds 123–124.
See this image and copyright information in PMC

References

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    1. Katritsky A.R., Rees C.W., Rees K.T., editors. Comprehensive Heterocyclic Chemistry: The Structurt, Reactions, Synthesis and Uses of Heterocyclic Compounds. 1st ed. Volume 5. Pergamon Press; Oxford, UK: 1984. pp. 791–838. Part 4A.
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    1. Benson F.R. Heterocylic Compounds. John Wiley & Sons, Inc.; New York, NY, USA: 1967. Theoretical principles of the chemistry of heterocycles; p. 1.
    1. Demko Z.P., Sharpless K.B. Preparation of 5-substituted-1H-tetrazoles from nitriles in water. J. Org. Chem. 2001;66:7945–7950. doi: 10.1021/jo010635w. - DOI - PubMed

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