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. 2015 Jun;33(6):770-5.
doi: 10.1016/j.ajem.2015.03.008. Epub 2015 Mar 12.

Clinical diagnosis of influenza in the ED

Andrea F Dugas  1 , Alexandra Valsamakis  2 , Mihir R Atreya  3 , Komal Thind  3 , Peter Alarcon Manchego  3 , Annum Faisal  3 , Charlotte A Gaydos  4 , Richard E Rothman  4
Affiliations

Clinical diagnosis of influenza in the ED

Andrea F Dugas et al. Am J Emerg Med. 2015 Jun.

Abstract

Background: Timely and accurate diagnosis of influenza remains a challenge but is critical for patients who may benefit from antiviral therapy. This study determined the test characteristics of provider diagnosis of influenza, final ED electronic medical record (EMR) diagnosis of influenza, and influenza-like illness (ILI) in patients recommended to receive antiviral treatment according to Centers for Disease Control and Prevention (CDC) guidelines. In addition, we evaluated the compliance with CDC antiviral guidelines.

Methods: A prospective cohort of adults presenting to a tertiary care ED with an acute respiratory illness who met CDC criteria for recommended antiviral treatment were enrolled and tested for influenza. A clinical diagnosis of influenza was assessed by asking the clinician: "Do you think this patient has influenza?" Influenza-like illness was defined according to current CDC criteria.

Results: In this cohort of 270 subjects, 42 (16%; 95% confidence interval [CI], 11%-20%) had influenza. Clinician diagnosis had a sensitivity of 36% (95% CI, 22%-52%) and specificity of 78% (95% CI, 72%-83%); EMR final ED diagnosis had a sensitivity of 26% (95% CI, 14%-42%) and specificity of 97% (95% CI, 94%-99%); ILI had a sensitivity of 31% (95% CI, 18%-47%) and specificity of 88% (95% CI, 83%-92%). Only 15 influenza-positive patients (36%) received antiviral treatment.

Conclusion: Clinician diagnosis, final ED EMR diagnosis, and ILI have low sensitivity for diagnosing influenza, and there is overall poor compliance with CDC antiviral treatment recommendations. Improved methods of influenza diagnosis are needed to help guide management in the clinical setting.

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Figures

Figure 1
Figure 1
Diagram Of Enrolled For Subjects Presenting To An Inner-city Emergency Department During The 2012-2013 Influenza Season With An Acute Respiratory Illness And Criteria To Indicate Antiviral Treatment According To Centers For Disease Control And Prevention Guidelines
See this image and copyright information in PMC

References

    1. Thompson WWS, Weintraub E, Brammer L, Bridges CB, Cox NJ, Fukuda K. Influenza-associated hospitalizations in the United States. JAMA. 2004;292:1333–40. D.K. - PubMed
    1. Thompson WW, Shay DK, Weintraub E, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA. 2003;289:179–86. - PubMed
    1. Fiore AE, Fry A, Shay D, Gubareva L, Bresee JS, Uyeki T. Centers for Disease Control and Prevention (CDC). Antiviral agents for the treatment and chemoprophylaxis of influenza --- recommendations of the Advisory Committee on Immunization Practices (ACIP) MMWR Surveill Summ. 2011;60:1–24. - PubMed
    1. Harper SA, Bradley JS, Englund JA, et al. Seasonal influenza in adults and children--diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis. 2009;48:1003–32. - PMC - PubMed
    1. WHO recommendations on the use of rapid testing for influenza diagnosis 2005 (Accessed March 12, 2013, at http://www.who.int/influenza/resources/documents/rapid_testing/en/index.....)

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