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Comment
. 2015 Apr 1;593(7):1527-8.
doi: 10.1113/JP270006.

All ON pathways are not alike

Catherine W Morgans  1
Affiliations
Comment

All ON pathways are not alike

Catherine W Morgans. J Physiol. .
No abstract available

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Figures

Figure 1
Figure 1
How light causes depolarization of ON-BPCs In the dark, mGluR6 binds to glutamate and activates Go. The alpha subunit of Go exchanges GDP for GTP and dissociates from the beta and gamma subunits. The βγ heterodimer maintains the TRPM1 channel in a closed state. In the light, the glutamate concentration in the synaptic cleft falls, inactivating mGluR6 and Go. Goα hydrolyses GTP to GDP, a process that is accelerated through interaction of Goα with RGS7 and RGS11. GDP-bound Goα recombines with the βγ subunits. TRPM1 opens and the inward current depolarizes the cell.
See this image and copyright information in PMC

Comment on

References

    1. Cao Y, Pahlberg J, Sarria I, Kamasawa N, Sampath AP. Martemyanov KA. Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons. Proc Natl Acad Sci USA. 2012;109:7905–7910. - PMC - PubMed
    1. Dhingra A, Ramakrishnan H, Neinstein A, Fina ME, Xu Y, Li J, Chung DC, Lyubarsky A. Vardi N. Gβ3is required for normal light ON responses and synaptic maintenance. J Neurosci. 2012;32:11343–11355. - PMC - PubMed
    1. Ramakrishnan H, Dhingra A, Tummala SR, Fina ME, Li JJ, Lyubarsky A. Vardi N. Differential function of Gγ13 in rod bipolar and ON cone bipolar cells. J Physiol. 2014;593:1531–1550. - PMC - PubMed
    1. Shen Y, Rampino MA, Carroll RC. Nawy S. G-protein-mediated inhibition of the Trp channel TRPM1 requires the Gβγ dimer. Proc Natl Acad Sci USA. 2012;109:8752–8757. - PMC - PubMed
    1. Szikra T, Trenholm S, Drinnenberg A, Juttner J, Farrow K, Biel M, Awatramani G, Clark DA, Sahel JA, da Silveira RA. Roska B. Rods in daylight act as relay cells for cone-driven horizontal cell-mediated surround inhibition. Nat Neurosci. 2014;17:1728–1735. - PubMed

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