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. 2015 May;4(5):532-7.
doi: 10.5966/sctm.2014-0199. Epub 2015 Mar 31.

Long-term results of adipose-derived stem cell therapy for the treatment of Crohn's fistula

Yong Beom Cho  1 , Kyu Joo Park  1 , Sang Nam Yoon  1 , Kee Ho Song  1 , Do Sun Kim  1 , Sang Hun Jung  1 , Mihyung Kim  1 , Hee Young Jeong  1 , Chang Sik Yu  2
Affiliations

Long-term results of adipose-derived stem cell therapy for the treatment of Crohn's fistula

Yong Beom Cho et al. Stem Cells Transl Med. 2015 May.

Abstract

A previous phase II clinical trial of adipose-derived stem cell (ASC) therapy for fistulae associated with Crohn's disease, a devastating condition with a high recurrence rate, demonstrated safety and therapeutic potential with a 1-year sustained response. In the present study, 41 of the 43 phase II trial patients were followed for an additional year, regardless of response in the initial year. At 24 months, complete healing was observed in 21 of 26 patients (80.8%) in modified per protocol analysis and 27 of 36 patients (75.0%) in modified intention-to-treat analysis. No adverse events related to ASC administration were observed. Furthermore, complete closure after initial treatment was well-sustained. These results strongly suggest that autologous ASCs may be a novel treatment option for Crohn's fistulae.

Keywords: Adipose-derived stem cells; Autologous stem cells; Complete closure of fistula; Crohn’s fistula; Sustained response.

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Figures

Figure 1.
Figure 1.
Patient disposition. Abbreviations: ASC, adipose-derived stem cell; F/U, follow-up; ITT, intention-to-treat; PP, per protocol; yrs; years.
See this image and copyright information in PMC

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