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. 2015 Apr;56(4):393-8.

Antimicrobial resistance trends among canine Escherichia coli isolates obtained from clinical samples in the northeastern USA, 2004-2011

Kevin J Cummings  1 , Victor A Aprea  1 , Craig Altier  1
Affiliations

Antimicrobial resistance trends among canine Escherichia coli isolates obtained from clinical samples in the northeastern USA, 2004-2011

Kevin J Cummings et al. Can Vet J. 2015 Apr.

Abstract
in English, French

Our objectives were to describe the antimicrobial susceptibility of Escherichia coli isolates from dogs in the northeastern USA and to identify temporal trends in resistance to selected antimicrobial agents. Data were collected retrospectively for all canine E. coli isolates from clinical samples submitted to Cornell University's Animal Health Diagnostic Center between January 1, 2004 and December 31, 2011. Antimicrobial susceptibility testing was performed on 3519 canine E. coli isolates; frequency of resistance to each agent ranged from 0.4% (amikacin) to 34.3% (ampicillin). No trends were evident among urinary isolates, but cephalosporin resistance remained consistently high. Among non-urinary isolates, there was evidence of a significantly increasing trend in prevalence of resistance to several agents, including cephalosporins, enrofloxacin, and tetracycline. These data suggest that some of the most commonly used antimicrobial agents in companion animal practice are becoming less effective against canine E. coli infections outside the urinary tract.

Tendances de la résistance antimicrobienne parmi les isolats canins d’Escherichia coliobtenus dans des échantillons cliniques dans le nord-est des États-Unis de 2004 à 2011. Nos objectifs consistaient à décrire la susceptibilité des isolats d’Escherichia coli chez des chiens dans le nord-est des États-Unis et à identifier les tendances de résistance temporelles aux agents antimicrobiens sélectionnés. Des données ont été recueillies rétrospectivement pour tous les isolats canins d’E. coli provenant d’échantillons cliniques soumis à l’Animal Health Diagnostic Center de l’Université Cornell entre le 1er janvier 2004 et le 31 décembre 2011. Des épreuves de sensibilité antimicrobienne ont été réalisées sur 3519 isolats canins E. coli; la fréquence de résistance à chaque agent allait de 0,4 % (amikacine) à 34,3 % (ampicilline). Aucunes tendances n’étaient évidentes parmi les isolats urinaires, mais la résistance à la céphalosporine demeurait constamment élevée. Parmi les isolats non urinaires, il y avait des preuves d’une tendance significative à la hausse de la prévalence de la résistance à plusieurs agents, y compris les céphalosporines, l’enrofloxacine et la tétracycline. Ces données suggèrent que certains des agents antimicrobiens les plus communément utilisés en pratique des animaux de compagnie deviennent de moins en moins efficaces contre les infections canines par E. coli à l’extérieur des voies urinaires.(Traduit par Isabelle Vallières).

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Figures

Figure 1
Figure 1
Resistance to individual antimicrobial agents among canine E. coli isolates stratified by sample source, 2004–2011. AMI — amikacin; AUG — amoxicillin/clavulanic acid; AMP — ampicillin; FAZ — cefazolin; FOX — cefoxitin; CEP — cephalothin; CHL — chloramphenicol; ENRO — enrofloxacin; GEN — gentamicin; TET — tetracycline; SXT — trimethoprim/sulfamethoxazole
Figure 2
Figure 2
Distribution of resistance by number of antimicrobial classes among 1161 canine E. coli isolates that were tested for susceptibility to all antimicrobial agents used in this study, 2004–2011.
Figure 3
Figure 3
A — Temporal trends in the prevalence of cephalosporin resistance among non-urinary E. coli isolates from dogs in the northeastern USA, 2004–2011. FAZ — cefazolin; FOX — cefoxitin; CEP — cephalothin B — Temporal trends in the prevalence of enrofloxacin and tetracycline resistance among non-urinary E. coli isolates from dogs in the northeastern USA, 2004–2011. ENRO — enrofloxacin; TET — tetracycline
See this image and copyright information in PMC

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