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Review
. 2015 Mar-Apr;18(2):83-8.
doi: 10.4103/0972-0707.153054.

Biotoxicity of commonly used root canal sealers: A meta-analysis

Amandeep Kaur  1 , Naseem Shah  1 , Ajay Logani  1 , Navin Mishra  1
Affiliations
Review

Biotoxicity of commonly used root canal sealers: A meta-analysis

Amandeep Kaur et al. J Conserv Dent. 2015 Mar-Apr.

Abstract

Introduction: The main objective of a root canal sealer is to provide a fluid tight seal. The purpose of this systematic meta-analysis was to determine the relative toxicity of commonly used root canal sealers like zinc oxide eugenol, calcium hydroxide, and resin-based sealers.

Materials and methods: An online search was conducted in peer-reviewed journals listed in PubMed, Cochrane, EBSCO, and IndMed databases between 2000 and 2012). Statistical analysis was carried out by using analysis of variance (ANOVA) followed by post-hoc comparison by Bonferroni method. The comparison between toxicity at 24 h and between 3 and 7 days was done by using paired t-test for each sealer.

Results: At 24 h, the relative biotoxicity of the three sealers reported was insignificant (P- value 0.29), but the difference in toxicity was found significant (P < 0.001) after 3 days.

Conclusion: Calcium hydroxide sealer and zinc oxide eugenol were found to be significantly biotoxic as compared to resin-based sealers after 3 days.

Keywords: Biocompatibility; cytotoxicity; meta-analysis; root canal sealers.

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Conflict of interest statement

Conflict of Interest: None declared.

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