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Case Reports
. 2015 Mar;50(1):51-3.
doi: 10.5045/br.2015.50.1.51. Epub 2015 Mar 24.

HBV reactivation in a HBsAg-negative patient with multiple myeloma treated with prednisolone maintenance therapy after autologous HSCT

Ha Ra Gu  1 , Dong-Yeop Shin  1 , Hong Seok Choi  1 , Chae Ho Moon  1 , Su Cheol Park  1 , Hye Jin Kang  1
Affiliations
Case Reports

HBV reactivation in a HBsAg-negative patient with multiple myeloma treated with prednisolone maintenance therapy after autologous HSCT

Ha Ra Gu et al. Blood Res. 2015 Mar.

Abstract

Hepatitis B virus (HBV) reactivation has previously occurred in hepatitis B surface antigen-negative patients with malignant lymphoma who received rituximab-based combination chemotherapy. However, few reports have described cases of HBV reactivation in patients with multiple myeloma thus far. We report a case of HBV reactivation in a patient with multiple myeloma treated with chemotherapy, autologous hematopoietic stem cell transplantation, and maintenance steroid therapy. For the HBV reactivation, the patient was treated with the antiviral agent entecavir. The clinical symptoms and laboratory findings improved after 3 months. Further studies should target the identification of patients at high risk of HBV reactivation in multiple myeloma treated with autologous hematopoietic stem cell transplantation and steroid therapy for maintenance and establish viral prophylaxis strategies, especially in Korea, in which HBV infection is endemic.

Keywords: Chemotherapy; HBV reactivation; Multiple myeloma; Prednisolone; Transplantation.

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Conflict of interest statement

Authors' Disclosures of Potential Conflicts of Interest: No potential conflicts of interest relevant to this article were reported.

Figures

Fig. 1
Fig. 1. Changes in the liver function panel after entecavir treatment.
See this image and copyright information in PMC

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