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. 1989 Nov;8(11):3401-7.
doi: 10.1002/j.1460-2075.1989.tb08504.x.

Autoregulation of RNase III operon by mRNA processing

J C Bardwell  1 , P Régnier, S M Chen, Y Nakamura, M Grunberg-Manago, D L Court
Affiliations

Autoregulation of RNase III operon by mRNA processing

J C Bardwell et al. EMBO J. 1989 Nov.

Abstract

RNase III has been implicated in the control of gene expression by the processing of mRNA. We have found that the rnc operon is autoregulated; rnc- mutant strains oversynthesize the operon's mRNA and protein products. A site in the 5'-noncoding region of the operon's message is cleaved by RNase III. This site-specific cleavage appears to be the initial step in the functional inactivation of the message, since the half-life of the cut message is dramatically shorter than that of the uncut message.

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References

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