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Review
. 2016 Apr;53(3):1905-1924.
doi: 10.1007/s12035-015-9143-0. Epub 2015 Apr 2.

The Essential Role of Soluble Aβ Oligomers in Alzheimer's Disease

Zi-Xuan Wang  1 , Lan Tan  2 , Jinyuan Liu  3 , Jin-Tai Yu  4   5
Affiliations
Review

The Essential Role of Soluble Aβ Oligomers in Alzheimer's Disease

Zi-Xuan Wang et al. Mol Neurobiol. 2016 Apr.

Abstract

Alzheimer's disease (AD) is a common neurodegenerative disease characterized by amyloid plaque and neurofibrillary tangles (NFT). With the finding that soluble nonfibrillar Aβ levels actually correlate strongly with the severity of the disease, the initial focus on amyloid plaques shifted to the contemporary concept that AD memory failure is caused by soluble Aβ oligomers. The soluble Aβ are known to be more neurotoxicthan fibrillar Aβ species. In this paper, we summarize the essential role of soluble Aβ oligomers in AD and discuss therapeutic strategies that target soluble Aβ oligomers.

Keywords: Alzheimer’ disease; Aβ; Soluble Aβ oligomers.

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References

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