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. 2015 Mar 17:9:493-7.
doi: 10.2147/OPTH.S74249. eCollection 2015.

Toxic anterior segment syndrome after uncomplicated cataract surgery possibly associated with intracamaral use of cefuroxime

Burçin Çakır  1 , Erkan Celik  1 , Nilgün Özkan Aksoy  1 , Özlem Bursalı  1 , Turgay Uçak  1 , Erdinç Bozkurt  1 , Gursoy Alagoz  1
Affiliations

Toxic anterior segment syndrome after uncomplicated cataract surgery possibly associated with intracamaral use of cefuroxime

Burçin Çakır et al. Clin Ophthalmol. .

Abstract

Purpose: To report toxic anterior segment syndrome (TASS) after cataract surgery possibly associated with intracameral use of cefuroxime.

Methods: We conducted a retrospective chart review and analysis on the pre- and postoperative conditions of the subjects who had developed TASS.

Results: The patient group consisted of 17 patients. Tyndallization and fibrin fibers were positive in all eyes. In four eyes, hypopyon formation developed. These reactions diminished on the third day and fully resolved 1 week after the operations with the use of intensive topical steroid and mydriatic therapy. To determine the etiology of TASS, infusion fluid, viscoelastics, and intracameral antibiotic agent were changed respectively. After changing intracameral antibiotic agent from cefuroxime axetile to moxifloxacin no new cases of TASS were diagnosed.

Conclusion: All agents injected into the anterior chamber can cause TASS. Ophthalmologists and operating room staff need to pay careful attention to all drugs and irrigating solutions.

Keywords: drug toxicity; fibrin reaction; phacoemulsification.

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Figures

Figure 1
Figure 1
Fibrin reaction extended as far as paracentesis.
Figure 2
Figure 2
Hypopyon formation.
See this image and copyright information in PMC

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