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. 2014 Dec;14(4):849-54.
doi: 10.4314/ahs.v14i4.12.

Mortality associated with tuberculosis/HIV co-infection among patients on TB treatment in the Limpopo province, South Africa

Tiyani E Mabunda  1 , Nalezani J Ramalivhana  2 , Yoswa M Dambisya  3
Affiliations

Mortality associated with tuberculosis/HIV co-infection among patients on TB treatment in the Limpopo province, South Africa

Tiyani E Mabunda et al. Afr Health Sci. 2014 Dec.

Abstract

Background: South Africa has a high tuberculosis burden, and Limpopo Province experienced higher than national average TB mortality rates between 1997 and 2008.

Objective: To establish factors associated with TB mortality in Limpopo Province in 2008.

Design: Retrospective study using provincial data for patients who died after commencing TB treatment between 01 January 2008 and 31 December 2008.

Results: In 2008, some 18074 patients started treatment: 15995 (88.5%) had pulmonsry TB (PTB), while 2079 (11.5%) had Extra pulmonary TB (EPTB). Overall, 2242 (12.4%) patients died, mainly PTB patients (n=1906; 85%), more males (n=1159, 51.7%), mainly those aged 25 to 54 years (n=1749, 78.0%), and new cases (1914; 85.4%). TB mortality was significantly higher among smear negative than smear positive patients (17% vs 13.8%; P<0.001), among those with EPTB compared to PTB patients (P<0.001), and among re-treatment cases (P<0.001). Only 4237 (23.4%) patients had HIV status known, with higher mortality found among HIV positive than the HIV negative patients (P<0.0001); but HIV status was not known for the majority who died (n=1685, 75.2%).

Conclusion: Higher mortality was associated with age 22-55 years; smear negativity, EPTB, HIV infection, and re-treatment. The findings call for greater integration of TB control efforts and HIV services, especially among the 22-55 year age group.

Keywords: Limpopo; South Afric; Tuberculosis/HIV.

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Figures

Figure 1
Figure 1
Age Range (Years) Distribution of Patients who died in 2008
Figure2
Figure2
Proportionate percentage of deaths per age group.
See this image and copyright information in PMC

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