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. 2015 Apr 5;128(7):896-901.
doi: 10.4103/0366-6999.154284.

Incidence and clinical characteristics of pulmonary hypertension in patients with idiopathic pulmonary fibrosis

Wei Yan, Li-Ying Peng, Cheng-Jun Ban, Xue-Feng Xu, Min Zhu, Yan Liu, Shu Zhang, Zhen-Guo Zhai, Chen Wang, Hua-Ping Dai  1
Affiliations

Incidence and clinical characteristics of pulmonary hypertension in patients with idiopathic pulmonary fibrosis

Wei Yan et al. Chin Med J (Engl). .

Abstract

Background: Pulmonary hypertension (PH) frequently complicates the course of idiopathic pulmonary fibrosis (IPF) patients and is associated with significantly worse outcomes. The aim of the present study was to investigate the incidence of PH in IPF patients and evaluate the correlation between clinical parameters and systolic pulmonary artery pressure (sPAP).

Methods: Hospitalized patients with IPF, who were evaluated for sPAP by Doppler echocardiography from January 2004 to December 2011, were enrolled in our study. Patients were defined as PH by an estimated sPAP > 50 mmHg and graded as PH likely, PH possible and PH unlikely, based on the 2009 European Society of Cardiology/European Respiratory Society PH Guidelines. The correlations between clinical parameters and sPAP were analyzed by multiple linear regression.

Results: Totally, 119 IPF patients were enrolled in our study and 28 (23.5%), 20 (16.8%) and 71 (59.7%) patients were PH likely, PH possible and PH unlikely, respectively. Borg dyspnea score was positively correlated with sPAP, r = 0.467, P < 0.001. Oxygen saturation was negatively correlated with sPAP, r = -0.416, P < 0.001. Diffusing capacity of the lung for carbon monoxide percentage predicted was negatively correlated with sPAP, r = -0.424, P = 0.003. N-terminal fragment of pro-brain natriuretic peptide and pulmonary artery width was positively correlated with sPAP, r = 0.452, P = 0.011 and r = 0.513, P < 0.001, respectively.

Conclusions: The incidence of PH in IPF patients was 23.5% in a single center of China. PH may worsen the dyspnea, right heart dysfunction and decrease the life quality of the patients with IPF.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Flow chart of the study population enrollment. ILD: Interstitial lung disease; CTD: Connective tissue disease; IPF: Idiopathic pulmonary fibrosis.
Figure 2
Figure 2
Correlation analysis between the pulmonary artery width and NT-pro BNP with sPAP in IPF patients, respectively. (a) A positive correlation was found between the pulmonary artery width and sPAP in subjects with IPF (r = 0.513, P < 0.001); (b) A positive correlation was found between NT-pro BNP and sPAP in subjects with IPF (r = 0.452, P = 0.011). Analysis was performed with the Spearman rank correlation coefficient and Pearson rank correlation coefficient. sPAP: Systolic pulmonary artery pressure; NT-pro BNP: N-terminal fragment of pro-BNP; IPF: Idiopathic pulmonary fibrosis.
See this image and copyright information in PMC

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