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Case Reports
. 2015 Apr 5;128(7):985-7.
doi: 10.4103/0366-6999.154329.

Small lymphocytic lymphoma/chronic lymphocytic leukemia with chromothripsis in an old woman

Li Tan  1 , Li-Hua Xu, Hai-Bo Liu, Shao-Jiang Yang
Affiliations
Case Reports

Small lymphocytic lymphoma/chronic lymphocytic leukemia with chromothripsis in an old woman

Li Tan et al. Chin Med J (Engl). .
No abstract available

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Cytogenetic studies of the bone marrow were performed using conventional cytogenetic techniques. The karyotypes were described according to the International System for Chromosome Nomenclature 2009.
Figure 2
Figure 2
(a) Fluorescence in situ hybridization showing multiple copies the C-MYC gene (red color); (b) and a deletion of the p53 gene (green color); (c) Depiction of DNA copy number in the abnormal chromosomes identified in marrow samples from this chronic lymphocytic leukemia/small lymphocytic lymphoma patient. For each chromosome shown, the red arrows depict the deletions of DNA copy number, and blue arrows depict the amplification of DNA copy number. Multiple oscillations between two DNA copy number stated in chromosomes 8, 9, 11, 13, 17, 19, and X indicative of chromothripsis. Numerous discontinuous deletions are indicated by red arrows and discontinuous amplification in chromosome arms 8q and 17q are indicated by blue arrows. In addition to these focal deletions, larger single deletions could be seen in chromosome arms 2q, 5p, 7q, and 14q.
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