Profiling invasiveness in head and neck cancer: recent contributions of genomic and transcriptomic approaches

doi:10.3390/cancers7020585

Review

. 2015 Mar 31;7(2):585-97.

doi: 10.3390/cancers7020585.

Profiling invasiveness in head and neck cancer: recent contributions of genomic and transcriptomic approaches

Lluís Nisa^{1

2

3}, Daniel Matthias Aebersold^{4

5}, Roland Giger⁶, Marco Domenico Caversaccio⁷, Urs Borner⁸, Michaela Medová^{9

10}, Yitzhak Zimmer^{11

12}

Affiliations

¹ Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. lluis.nisa@dkf.unibe.ch.
² Department of Clinical Research, Inselspital, Bern University Hospital, and University of Bern, MEM-E807, Murtenstrasse 35, Bern 3010, Switzerland. lluis.nisa@dkf.unibe.ch.
³ Department of Otorhinolaryngology-Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. lluis.nisa@dkf.unibe.ch.
⁴ Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. daniel.aebersold@insel.ch.
⁵ Department of Clinical Research, Inselspital, Bern University Hospital, and University of Bern, MEM-E807, Murtenstrasse 35, Bern 3010, Switzerland. daniel.aebersold@insel.ch.
⁶ Department of Otorhinolaryngology-Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. roland.giger@insel.ch.
⁷ Department of Otorhinolaryngology-Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. marco.caversaccio@insel.ch.
⁸ Department of Otorhinolaryngology-Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. urs.borner@insel.ch.
⁹ Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. michaela.medova@dkf.unibe.ch.
¹⁰ Department of Clinical Research, Inselspital, Bern University Hospital, and University of Bern, MEM-E807, Murtenstrasse 35, Bern 3010, Switzerland. michaela.medova@dkf.unibe.ch.
¹¹ Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. yitzhak.zimmer@insel.ch.
¹² Department of Clinical Research, Inselspital, Bern University Hospital, and University of Bern, MEM-E807, Murtenstrasse 35, Bern 3010, Switzerland. yitzhak.zimmer@insel.ch.

PMID: 25836654
PMCID: PMC4491672
DOI: 10.3390/cancers7020585

Review

Profiling invasiveness in head and neck cancer: recent contributions of genomic and transcriptomic approaches

Lluís Nisa et al. Cancers (Basel). 2015.

. 2015 Mar 31;7(2):585-97.

doi: 10.3390/cancers7020585.

Authors

Lluís Nisa^{1

2

3}, Daniel Matthias Aebersold^{4

5}, Roland Giger⁶, Marco Domenico Caversaccio⁷, Urs Borner⁸, Michaela Medová^{9

10}, Yitzhak Zimmer^{11

12}

Affiliations

¹ Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. lluis.nisa@dkf.unibe.ch.
² Department of Clinical Research, Inselspital, Bern University Hospital, and University of Bern, MEM-E807, Murtenstrasse 35, Bern 3010, Switzerland. lluis.nisa@dkf.unibe.ch.
³ Department of Otorhinolaryngology-Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. lluis.nisa@dkf.unibe.ch.
⁴ Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. daniel.aebersold@insel.ch.
⁵ Department of Clinical Research, Inselspital, Bern University Hospital, and University of Bern, MEM-E807, Murtenstrasse 35, Bern 3010, Switzerland. daniel.aebersold@insel.ch.
⁶ Department of Otorhinolaryngology-Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. roland.giger@insel.ch.
⁷ Department of Otorhinolaryngology-Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. marco.caversaccio@insel.ch.
⁸ Department of Otorhinolaryngology-Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. urs.borner@insel.ch.
⁹ Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. michaela.medova@dkf.unibe.ch.
¹⁰ Department of Clinical Research, Inselspital, Bern University Hospital, and University of Bern, MEM-E807, Murtenstrasse 35, Bern 3010, Switzerland. michaela.medova@dkf.unibe.ch.
¹¹ Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. yitzhak.zimmer@insel.ch.
¹² Department of Clinical Research, Inselspital, Bern University Hospital, and University of Bern, MEM-E807, Murtenstrasse 35, Bern 3010, Switzerland. yitzhak.zimmer@insel.ch.

PMID: 25836654
PMCID: PMC4491672
DOI: 10.3390/cancers7020585

Abstract

High-throughput molecular profiling approaches have emerged as precious research tools in the field of head and neck translational oncology. Such approaches have identified and/or confirmed the role of several genes or pathways in the acquisition/maintenance of an invasive phenotype and the execution of cellular programs related to cell invasion. Recently published new-generation sequencing studies in head and neck squamous cell carcinoma (HNSCC) have unveiled prominent roles in carcinogenesis and cell invasion of mutations involving NOTCH1 and PI3K-patwhay components. Gene-expression profiling studies combined with systems biology approaches have allowed identifying and gaining further mechanistic understanding into pathways commonly enriched in invasive HNSCC. These pathways include antigen-presenting and leucocyte adhesion molecules, as well as genes involved in cell-extracellular matrix interactions. Here we review the major insights into invasiveness in head and neck cancer provided by high-throughput molecular profiling approaches.

PubMed Disclaimer

Figures

**Figure 1**
Most relevant mechanisms of cell invasion outlined by high-throughput profiling studies in head and neck squamous cell carcinoma (HNSCC).

See this image and copyright information in PMC

Cited by

Sonic hedgehog in oral squamous cell carcinoma: An immunohistochemical study.
Srinath S, Iyengar AR, Mysorekar V. Srinath S, et al. J Oral Maxillofac Pathol. 2016 Sep-Dec;20(3):377-383. doi: 10.4103/0973-029X.190906. J Oral Maxillofac Pathol. 2016. PMID: 27721600 Free PMC article.
Analysis of Site-Specific Methylation of Tumor-Related Genes in Head and Neck Cancer: Potential Utility as Biomarkers for Prognosis.
Misawa K, Mochizuki D, Imai A, Mima M, Misawa Y, Mineta H. Misawa K, et al. Cancers (Basel). 2018 Jan 22;10(1):27. doi: 10.3390/cancers10010027. Cancers (Basel). 2018. PMID: 29361757 Free PMC article.
Current Insights and Advancements in Head and Neck Cancer: Emerging Biomarkers and Therapeutics with Cues from Single Cell and 3D Model Omics Profiling.
Jawa Y, Yadav P, Gupta S, Mathan SV, Pandey J, Saxena AK, Kateriya S, Tiku AB, Mondal N, Bhattacharya J, Ahmad S, Chaturvedi R, Tyagi RK, Tandon V, Singh RP. Jawa Y, et al. Front Oncol. 2021 Aug 17;11:676948. doi: 10.3389/fonc.2021.676948. eCollection 2021. Front Oncol. 2021. PMID: 34490084 Free PMC article. Review.
The Epstein-Barr virus EBNA2 protein induces a subset of NOTCH target genes in thyroid cancer cell lines but fails to suppress proliferation.
Golden S, Yu XM, Odorico S, Jain V, Marin A, Ma S, Kenney S, Chen H. Golden S, et al. Surgery. 2017 Jan;161(1):195-201. doi: 10.1016/j.surg.2016.06.068. Epub 2016 Nov 12. Surgery. 2017. PMID: 27847111 Free PMC article.
uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy.
Pavón MA, Arroyo-Solera I, Céspedes MV, Casanova I, León X, Mangues R. Pavón MA, et al. Oncotarget. 2016 Aug 30;7(35):57351-57366. doi: 10.18632/oncotarget.10344. Oncotarget. 2016. PMID: 27385000 Free PMC article. Review.

See all "Cited by" articles

References

1. Argiris A., Karamouzis M.V., Raben D., Ferris R.L. Head and neck cancer. Lancet. 2008;371:1695–1709. - PMC - PubMed
1. Jemal A., Siegel R., Xu J., Ward E. Cancer statistics, 2010. CA Cancer J. Clin. 2010;60:277–300. - PubMed
1. Goodwin W.J., Jr. Salvage surgery for patients with recurrent squamous cell carcinoma of the upper aerodigestive tract: When do the ends justify the means? Laryngoscope. 2000;110:1–18. - PubMed
1. Bonner J.A., Harari P.M., Giralt J., Cohen R.B., Jones C.U., Sur R.K., Raben D., Baselga J., Spencer S.A., Zhu J., et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010;11:21–28. - PubMed
1. Chaturvedi A.K., Engels E.A., Pfeiffer R.M., Hernandez B.Y., Xiao W., Kim E., Jiang B., Goodman M.T., Sibug-Saber M., Cozen W., et al. Human papillomavirus and rising oropharyngeal cancer incidence in the united states. J. Clin. Oncol. 2011;29:4294–4301. - PMC - PubMed

Publication types

Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

[1] Argiris A., Karamouzis M.V., Raben D., Ferris R.L. Head and neck cancer. Lancet. 2008;371:1695–1709. - PMC - PubMed

[2] Argiris A., Karamouzis M.V., Raben D., Ferris R.L. Head and neck cancer. Lancet. 2008;371:1695–1709. - PMC - PubMed

[3] Jemal A., Siegel R., Xu J., Ward E. Cancer statistics, 2010. CA Cancer J. Clin. 2010;60:277–300. - PubMed

[4] Jemal A., Siegel R., Xu J., Ward E. Cancer statistics, 2010. CA Cancer J. Clin. 2010;60:277–300. - PubMed

[5] Goodwin W.J., Jr. Salvage surgery for patients with recurrent squamous cell carcinoma of the upper aerodigestive tract: When do the ends justify the means? Laryngoscope. 2000;110:1–18. - PubMed

[6] Goodwin W.J., Jr. Salvage surgery for patients with recurrent squamous cell carcinoma of the upper aerodigestive tract: When do the ends justify the means? Laryngoscope. 2000;110:1–18. - PubMed

[7] Bonner J.A., Harari P.M., Giralt J., Cohen R.B., Jones C.U., Sur R.K., Raben D., Baselga J., Spencer S.A., Zhu J., et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010;11:21–28. - PubMed

[8] Bonner J.A., Harari P.M., Giralt J., Cohen R.B., Jones C.U., Sur R.K., Raben D., Baselga J., Spencer S.A., Zhu J., et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010;11:21–28. - PubMed

[9] Chaturvedi A.K., Engels E.A., Pfeiffer R.M., Hernandez B.Y., Xiao W., Kim E., Jiang B., Goodman M.T., Sibug-Saber M., Cozen W., et al. Human papillomavirus and rising oropharyngeal cancer incidence in the united states. J. Clin. Oncol. 2011;29:4294–4301. - PMC - PubMed

[10] Chaturvedi A.K., Engels E.A., Pfeiffer R.M., Hernandez B.Y., Xiao W., Kim E., Jiang B., Goodman M.T., Sibug-Saber M., Cozen W., et al. Human papillomavirus and rising oropharyngeal cancer incidence in the united states. J. Clin. Oncol. 2011;29:4294–4301. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Profiling invasiveness in head and neck cancer: recent contributions of genomic and transcriptomic approaches

Affiliations

Profiling invasiveness in head and neck cancer: recent contributions of genomic and transcriptomic approaches

Authors

Affiliations

Abstract

Figures

Similar articles

Cited by

References

Publication types

LinkOut - more resources

Full Text Sources

Other Literature Sources

Abstract

Figures

Similar articles

Cited by

References

Publication types

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources