Negative regulation of hepatitis B virus replication by forkhead box protein A in human hepatoma cells
- PMID: 25836733
- DOI: 10.1016/j.febslet.2015.03.022
Negative regulation of hepatitis B virus replication by forkhead box protein A in human hepatoma cells
Abstract
Hepatitis B virus (HBV) replication is controlled by liver-enriched transcriptional factors, including forkhead box protein A (FOXA) members. Here, we found that FOXA members are directly and indirectly involved in HBV replication in human hepatic cells. HBV replication was elevated in HuH-7 treated with individual FOXA members-specific siRNA. Reciprocally, the downregulation of HBV replication was observed in FOXA-induced HuH-7. However, the mechanism of downregulation is different among FOXA members at the level of HBV RNA transcription, such as precore/pg RNA and 2.1 kb RNA. In addition, FOXA1 and FOXA2 suppressed nuclear hormone receptors, such as HNF4α, that are related to HBV replication.
Keywords: FOXA1; FOXA2; FOXA3; HNF3; Hepatitis B virus; Hepatitis B virus replication.
Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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