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. 2015 Apr 28;589(10):1112-8.
doi: 10.1016/j.febslet.2015.03.022. Epub 2015 Mar 30.

Negative regulation of hepatitis B virus replication by forkhead box protein A in human hepatoma cells

Nobuaki Okumura  1 , Masanori Ikeda  2 , Shinya Satoh  3 , Hiromichi Dansako  3 , Masaya Sugiyama  4 , Masashi Mizokami  4 , Nobuyuki Kato  3
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Free article

Negative regulation of hepatitis B virus replication by forkhead box protein A in human hepatoma cells

Nobuaki Okumura et al. FEBS Lett. .
Free article

Abstract

Hepatitis B virus (HBV) replication is controlled by liver-enriched transcriptional factors, including forkhead box protein A (FOXA) members. Here, we found that FOXA members are directly and indirectly involved in HBV replication in human hepatic cells. HBV replication was elevated in HuH-7 treated with individual FOXA members-specific siRNA. Reciprocally, the downregulation of HBV replication was observed in FOXA-induced HuH-7. However, the mechanism of downregulation is different among FOXA members at the level of HBV RNA transcription, such as precore/pg RNA and 2.1 kb RNA. In addition, FOXA1 and FOXA2 suppressed nuclear hormone receptors, such as HNF4α, that are related to HBV replication.

Keywords: FOXA1; FOXA2; FOXA3; HNF3; Hepatitis B virus; Hepatitis B virus replication.

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