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Case Reports
. 2015;11(3):680-1.
doi: 10.1080/21645515.2015.1011960.

Successful therapy with bevacizumab in a case of hereditary hemorrhagic telangiectasia

J Kochanowski  1 , M Sobieszczańska, S Tubek, M Żurek, J Pawełczak
Affiliations
Case Reports

Successful therapy with bevacizumab in a case of hereditary hemorrhagic telangiectasia

J Kochanowski et al. Hum Vaccin Immunother. 2015.

Abstract

Hereditary hemorrhagic telangiectasia (HHT), genetic disorder manifested by uncontrolled multisystem angiogenesis with epistaxis, gastrointestinal bleeding, iron-deficiency anaemia, and arteriovenous malformations (AVM) is often related with increased levels of vascular endothelial growth factor (VEGF). Bevacizumab, a VEGF inhibitor, reduces epistaxis, telangiectasias, and iron-deficiency anaemia. A case of a female patient with HHT and chronic gastrointestinal bleeding is presented. The patient required iron supplementation and multiple blood transfusions. Bevacizumab brought marked symptomatic improvement and allowed for transfusion-independence. It is intended to apply for approval of the indications for bevacizumab administration in HHT as the 'orphan drug'.

Keywords: arteriovenosous malformations; bevacizumab; dosing; epistaxis; hereditary hemorrhagic telangiectasia (HHT); vascular endothelial growth factor (VEGF).

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