New genetic variants of influenza A(H1N1)pdm09 detected in Cuba during 2011-2013

Affiliations

¹ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: amely@ipk.sld.cu.
² Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: betsy@ipk.sld.cu.
³ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: Mayra@ipk.sld.cu.
⁴ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: odalys@ipk.sld.cu.
⁵ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: leandrofg@ipk.sld.cu.
⁶ Nacional Center for Biological, Carretera de Beltrán, Km. 1 1/2, Bejucal, Mayabeque, La Habana, Cuba. Electronic address: isel.medina@biocen.cu.
⁷ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: clara@ipk.sld.cu.
⁸ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: s.oro@ipk.sld.cu.
⁹ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: greg@ipk.sld.cu.
¹⁰ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: rroque@ipk.sld.cu.
¹¹ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: gglezb@ipk.sld.cu.
¹² Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: babyh@ipk.sld.cu.
¹³ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: goyenechea@ipk.sld.cu.
¹⁴ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: alexpr@ipk.sld.cu.

PMID: 25839842
DOI: 10.1016/j.meegid.2015.03.028

New genetic variants of influenza A(H1N1)pdm09 detected in Cuba during 2011-2013

Amely Arencibia et al. Infect Genet Evol. 2015 Jun.

. 2015 Jun:32:322-6.

doi: 10.1016/j.meegid.2015.03.028. Epub 2015 Mar 31.

Authors

Affiliations

¹ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: amely@ipk.sld.cu.
² Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: betsy@ipk.sld.cu.
³ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: Mayra@ipk.sld.cu.
⁴ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: odalys@ipk.sld.cu.
⁵ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: leandrofg@ipk.sld.cu.
⁶ Nacional Center for Biological, Carretera de Beltrán, Km. 1 1/2, Bejucal, Mayabeque, La Habana, Cuba. Electronic address: isel.medina@biocen.cu.
⁷ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: clara@ipk.sld.cu.
⁸ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: s.oro@ipk.sld.cu.
⁹ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: greg@ipk.sld.cu.
¹⁰ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: rroque@ipk.sld.cu.
¹¹ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: gglezb@ipk.sld.cu.
¹² Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: babyh@ipk.sld.cu.
¹³ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: goyenechea@ipk.sld.cu.
¹⁴ Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apdo, Postal 601, Marianao 13, La Habana 17100, Cuba. Electronic address: alexpr@ipk.sld.cu.

PMID: 25839842
DOI: 10.1016/j.meegid.2015.03.028

Abstract

Influenza A(H1N1)pdm09 virus has evolved continually since its emergence in 2009. For influenza virus strains, genetic changes occurring in HA1 domain of the hemagglutinin cause the emergence of new variants. The aim of our study is to establish genetic associations between 35 A(H1N1)pdm09 viruses circulating in Cuba in 2011-2012 and 2012-2013 seasons, and A/California/07/2009 strain recommended by WHO as the H1N1 component of the influenza vaccine. The phylogenetic analysis revealed the circulation of clades 3, 6A, 6B, 6C and 7. Mutations were detected in the antigenic site or in the receptor-binding domains of HA1 segment, including S174P, S179N, K180Q, S202T, S220T and R222K. Substitutions S174P, S179N, K180Q and R222K were detected in Cuban strains for the first time.

Keywords: Cuba; Genetic variants; Influenza.

PubMed Disclaimer

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
Medical
- MedlinePlus Health Information
Research Materials
- NCI CPTC Antibody Characterization Program

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

New genetic variants of influenza A(H1N1)pdm09 detected in Cuba during 2011-2013

Affiliations

New genetic variants of influenza A(H1N1)pdm09 detected in Cuba during 2011-2013

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Research Materials