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. 1989 Nov;42(11):1653-60.
doi: 10.7164/antibiotics.42.1653.

C(3)-cyclopropyl cephems and carbacephems

D O Spry  1 , N J Snyder, J S Kasher
Affiliations
Free article

C(3)-cyclopropyl cephems and carbacephems

D O Spry et al. J Antibiot (Tokyo). 1989 Nov.
Free article

Abstract

A series of C(3)-cyclopropyl cephems and carbacephems has been prepared by palladium catalyzed addition of diazomethane to the corresponding C(3)-vinyl derivatives. The phenylglycyl cyclopropyl cephem derivatives exhibit better Gram-positive activity than cephalexin or cefaclor, while the aminothiazole oxime cyclopropyl cephem derivatives were not as active as the corresponding C(3)-vinyl cephems.

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