Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jul 5:758:11-5.
doi: 10.1016/j.ejphar.2015.03.062. Epub 2015 Apr 3.

Nalbuphine could decrease the rewarding effect induced by tramadol in mice while enhancing its antinociceptive activity

Rasha Abdel-Ghany  1 , Mahmoud Nabil  1 , Mohamed Abdel-Aal  1 , Waleed Barakat  2
Affiliations

Nalbuphine could decrease the rewarding effect induced by tramadol in mice while enhancing its antinociceptive activity

Rasha Abdel-Ghany et al. Eur J Pharmacol. .

Abstract

Nalbuphine, a kappa-opioid agonist and mu-opioid partial agonist, has been used as an analgesic or an adjuvant with morphine to attenuate the development of morphine dependence and rewarding effect. In this study, we investigated the effect of nalbuphine on tramadol rewarding effect and antinociception. Using the conditioned place preference (CPP) paradigm in mice, we demonstrated that co-administration of nalbuphine (7mg/kg, s.c.) with tramadol (70mg/kg, s.c.) during conditioning completely blocked the CPP induced by tramadol. Co-administration of nalbuphine blocked the increase in dopamine level in the nucleus accumbens induced by tramadol. These actions were accompanied by an increase rather than attenuation of the antinociceptive effect of tramadol. These results suggest that nalbuphine could have a great potential as a pharmacotherapy for tramadol abuse.

Keywords: Nalbuphine; Psychological dependence; Reward; Tramadol.

PubMed Disclaimer

LinkOut - more resources