Ureteral metastasis of a prostatic adenocarcinoma

Abstract

The ureter is a rare location of metastasis for any kind of primary tumour. The first case of truly ureteral metastasis was described by Stow in 1909. Regarding prostatic metastasis, the frequency is much lower with only 43 cases reported in the last century. We present a case of an exceedingly rare ureteral metastasis of a prostatic adenocarcinoma. In spite of its low incidence, it should be considered in patients with ureteral obstruction and concurrent prostatic adenocarcinoma.

Fig. 1.

Endoscopic view of the metastasis.

Fig. 2a.

Photomicrograph obtained from ureteral biopsy. Hematoxylin and eosin stain stained section revealed a fragment of the ureteral wall partially coated by urothelium (blue arrow). The corium shows a tumour cell proliferation with an infiltrating pattern (original magnification ×40).

Fig. 2b.

Subepithelial connective tissue infiltrated by tumour cells arranged in a pattern of nests and single cell with irregular and hyperchromatic nuclei some with patent nucleolus (hematoxylin and eosin original magnification ×400).

Fig. 2c.

Immunohistochemical staining revealed the vast majority of tumour cells in different areas weak cytoplasmic positivity for prostate-specific antigen (original magnification ×1000).