Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Mar;29(6):972-6.
doi: 10.3109/14767058.2015.1027680. Epub 2015 Sep 25.

Reference values of serum IgG and IgM levels in preterm and term newborns

Senem Alkan Ozdemir  1 , Esra Arun Ozer  1 , Sukran Kose  2 , Ozkan Ilhan  1 , Can Ozturk  3 , Sumer Sutcuoglu  1
Affiliations

Reference values of serum IgG and IgM levels in preterm and term newborns

Senem Alkan Ozdemir et al. J Matern Fetal Neonatal Med. 2016 Mar.

Abstract

Aim: Although, variations of normal immunoglobulin (Ig) levels in different gestational age and birth weight groups have been studied so far, data are still limited in newborns, especially in preterm infants. The aim of this study was to determine serum IgG and IgM levels in newborns in order to generate a reference standard for neonatal intensive care unit (NICU) and address the variations in preterm babies.

Methods: This study was conducted from June 2012 to June 2013 in a level III NICU. A total of 300 newborn infants hospitalized within first 72 h were included in the study. The quantification of serum IgG and IgM was performed by nephelometric method.

Results: Both serum IgG and IgM levels were increased in correlation with increased gestational age and birth weight.

Conclusion: The reference values of serum IgG and IgM levels should be further evaluated in larger series with the presented data in this article. In addition, preterm babies appear to have lower Ig levels thus carry the risk of relevant morbidity.

Keywords: IgG; IgM; immunoglobulin; newborn; preterm.

PubMed Disclaimer

LinkOut - more resources