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. 2015;59(6):3652-5.
doi: 10.1128/AAC.00029-15. Epub 2015 Apr 6.

Colonization of extended-spectrum-β-lactamase- and NDM-1-producing Enterobacteriaceae among pregnant women in the community in a low-income country: a potential reservoir for transmission of multiresistant Enterobacteriaceae to neonates

Fanny Chereau  1 , Perlinot Herindrainy  2 , Benoit Garin  3 , Bich-Tram Huynh  4 , Frederique Randrianirina  5 , Michael Padget  4 , Patrice Piola  2 , Didier Guillemot  6 , Elisabeth Delarocque-Astagneau  4
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Colonization of extended-spectrum-β-lactamase- and NDM-1-producing Enterobacteriaceae among pregnant women in the community in a low-income country: a potential reservoir for transmission of multiresistant Enterobacteriaceae to neonates

Fanny Chereau et al. Antimicrob Agents Chemother. 2015.

Abstract

The spread of extended-spectrum-β-lactamase-producing Enterobacteriaceae (ESBL-PE) in low-income countries, where the burden of neonatal sepsis is high, may have a serious impact on neonatal mortality rates. Given the potential for mother-to-child transmission of multiresistant bacteria, this study investigated the ESBL-PE rectal colonization among pregnant women at delivery in the community in Madagascar and estimated a prevalence of 18.5% (95% confidence interval, 14.5% to 22.6%). One strain of Klebsiella pneumoniae isolated was also a New Delhi metallo-β-lactamase-1 (NDM-1) producer.

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References

    1. Seale AC, Blencowe H, Manu AA, Nair H, Bahl R, Qazi SA, Zaidi AK, Berkley JA, Cousens SN, Lawn JE. 2014. Estimates of possible severe bacterial infection in neonates in sub-Saharan Africa, south Asia, and Latin America for 2012: a systematic review and meta-analysis. Lancet Infect Dis 14:731–741. doi:10.1016/S1473-3099(14)70804-7. - DOI - PMC - PubMed
    1. Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, Rudan I, Campbell H, Cibulskis R, Li M, Mathers C, Black RE. 2012. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet 379:2151–2161. doi:10.1016/S0140-6736(12)60560-1. - DOI - PubMed
    1. Zaidi AKM, Huskins WC, Thaver D, Bhutta ZA, Abbas Z, Goldmann DA. 2005. Hospital-acquired neonatal infections in developing countries. Lancet 365:1175–1188. doi:10.1016/S0140-6736(05)71881-X. - DOI - PubMed
    1. Waters D, Jawad I, Ahmad A, Lukšić I, Nair H, Zgaga L, Theodoratou E, Rudan I, Zaidi AKM, Campbell H. 2011. Aetiology of community-acquired neonatal sepsis in low and middle income countries. J Glob Health 1:154–170. - PMC - PubMed
    1. Bush K. 2010. Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae. Curr Opin Microbiol 13:558–564. doi:10.1016/j.mib.2010.09.006. - DOI - PubMed

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