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. 2015;59(6):3652-5.
doi: 10.1128/AAC.00029-15. Epub 2015 Apr 6.

Colonization of extended-spectrum-β-lactamase- and NDM-1-producing Enterobacteriaceae among pregnant women in the community in a low-income country: a potential reservoir for transmission of multiresistant Enterobacteriaceae to neonates

Fanny Chereau  1 , Perlinot Herindrainy  2 , Benoit Garin  3 , Bich-Tram Huynh  4 , Frederique Randrianirina  5 , Michael Padget  4 , Patrice Piola  2 , Didier Guillemot  6 , Elisabeth Delarocque-Astagneau  4
Affiliations

Colonization of extended-spectrum-β-lactamase- and NDM-1-producing Enterobacteriaceae among pregnant women in the community in a low-income country: a potential reservoir for transmission of multiresistant Enterobacteriaceae to neonates

Fanny Chereau et al. Antimicrob Agents Chemother. 2015.

Abstract

The spread of extended-spectrum-β-lactamase-producing Enterobacteriaceae (ESBL-PE) in low-income countries, where the burden of neonatal sepsis is high, may have a serious impact on neonatal mortality rates. Given the potential for mother-to-child transmission of multiresistant bacteria, this study investigated the ESBL-PE rectal colonization among pregnant women at delivery in the community in Madagascar and estimated a prevalence of 18.5% (95% confidence interval, 14.5% to 22.6%). One strain of Klebsiella pneumoniae isolated was also a New Delhi metallo-β-lactamase-1 (NDM-1) producer.

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