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. 2015 Aug;103(8):733-40.
doi: 10.1002/bdra.23373. Epub 2015 Apr 6.

Next steps for birth defects research and prevention: The birth defects study to evaluate pregnancy exposures (BD-STEPS)

Sarah C Tinker  1 , Suzan L Carmichael  2 , Marlene Anderka  3 , Marilyn L Browne  4 , Kristin M Caspers Conway  5 , Robert E Meyer  6 , Wendy N Nembhard  7 , Richard S Olney  1 , Jennita Reefhuis  1 ; Birth Defects Study To Evaluate Pregnancy exposureS
Affiliations

Next steps for birth defects research and prevention: The birth defects study to evaluate pregnancy exposures (BD-STEPS)

Sarah C Tinker et al. Birth Defects Res A Clin Mol Teratol. 2015 Aug.

Abstract

Background: The Birth Defects Study To Evaluate Pregnancy exposureS (BD-STEPS) is a population-based, multi-Center case-control study of modifiable risk factors for selected birth defects in the United States. BD-STEPS is the second major research effort of the Centers for Birth Defects Research and Prevention, which extends and expands the initial research effort, the National Birth Defects Prevention Study (NBDPS).

Methods: BD-STEPS focuses on 17 categories of structural birth defects selected based on severity, prevalence, consistent ascertainment, and previous findings that warrant additional research. Cases are identified through existing birth defects surveillance programs; controls are from vital records or birth hospital logs from the same catchment area. BD-STEPS uses a standardized computer-assisted telephone interview to collect information from case and control mothers on topics including demographics, health conditions, and medication use. Following the maternal interview, selected Centers request permission to sample residual newborn screening blood spots from state repositories for genetic analyses. New components planned for BD-STEPS include linkages with external datasets and use of online questionnaires to collect in-depth information on selected exposures.

Results: BD-STEPS extends NBDPS by continuing to collect data on many exposures that were assessed in NBDPS, allowing data from both studies to be combined and providing an unprecedented sample size to analyze rare exposures. BD-STEPS expands upon NBDPS by collecting more detailed information on existing exposures as well as new exposures.

Conclusion: The goal of BD-STEPS is to provide women and healthcare providers with information they need to make decisions to promote the healthiest pregnancy possible.

Keywords: birth defects; case-control; congenital anomalies; epidemiology; pregnancy.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

References

    1. Akinbami LJ, Moorman JE, Bailey C, Zahran HS, King M, Johnson CA, Liu X. Trends in asthma prevalence, health care use, and mortality in the United States, 2001–2010. NCHS data brief. 2012;(94):1–8. - PubMed
    1. Alwan S, Reefhuis J, Rasmussen SA, Olney RS, Friedman JM National Birth Defects Prevention S. Use of selective serotonin-reuptake inhibitors in pregnancy and the risk of birth defects. The New England journal of medicine. 2007;356(26):2684–2692. - PubMed
    1. Anderka MT, Lin AE, Abuelo DN, Mitchell AA, Rasmussen SA. Reviewing the evidence for mycophenolate mofetil as a new teratogen: case report and review of the literature. American journal of medical genetics Part A. 2009;149A (6):1241–1248. - PubMed
    1. Belogolovkin V, Salihu HM, Weldeselasse H, Biroscak BJ, August EM, Mbah AK, Alio AP. Impact of prior bariatric surgery on maternal and fetal outcomes among obese and non-obese mothers. Archives of gynecology and obstetrics. 2012;285(5):1211–1218. - PubMed

    1. Boston University Slone Epidemiology Center PRESTO (Pregnancy Study Online).

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