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. 2015 May 1;51(35):7550-3.
doi: 10.1039/c5cc01814e.

Novel olfactory ligands via terpene synthases

Sabrina Touchet  1 , Keith Chamberlain, Christine M Woodcock, David J Miller, Michael A Birkett, John A Pickett, Rudolf K Allemann
Affiliations

Novel olfactory ligands via terpene synthases

Sabrina Touchet et al. Chem Commun (Camb). .

Abstract

A synthetic biology approach to the rational design of analogues of olfactory ligands by providing unnatural substrates for the enzyme synthesising (S)-germacrene D, an olfactory ligand acting as a plant derived insect repellent, to produce novel ligands is described as a viable alternative to largely unsuccessful ligand docking studies. (S)-14,15-Dimethylgermacrene D shows an unexpected reversal in behavioural activity.

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