Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2015 Apr;5(4):351-2.
doi: 10.1158/2159-8290.CD-15-0230.

miRSNP-Based Approach Identifies a miRNA That Regulates Prostate-Specific Antigen in an Allele-Specific Manner

George M Yousef  1
Affiliations
Comment

miRSNP-Based Approach Identifies a miRNA That Regulates Prostate-Specific Antigen in an Allele-Specific Manner

George M Yousef. Cancer Discov. 2015 Apr.

Abstract

A recent study identified genetic variations within the miRNA response elements of miRNA target genes (miRSNP) that can affect the base paring between miRNAs and their targets, and hence alter miRNA-target interactions. The authors also undertook functional validation studies and were able to demonstrate that overexpression of miR-3162-5p resulted in a 20% decrease in expression of the KLK3 rs1058205 SNP T-allele.

PubMed Disclaimer

Comment on

  • A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer.
    Stegeman S, Amankwah E, Klein K, O'Mara TA, Kim D, Lin HY, Permuth-Wey J, Sellers TA, Srinivasan S, Eeles R, Easton D, Kote-Jarai Z, Amin Al Olama A, Benlloch S, Muir K, Giles GG, Wiklund F, Gronberg H, Haiman CA, Schleutker J, Nordestgaard BG, Travis RC, Neal D, Pharoah P, Khaw KT, Stanford JL, Blot WJ, Thibodeau S, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Kaneva R, Teixeira MR; PRACTICAL Consortium; Australian Prostate Cancer BioResource; Spurdle AB, Clements JA, Park JY, Batra J. Stegeman S, et al. Cancer Discov. 2015 Apr;5(4):368-79. doi: 10.1158/2159-8290.CD-14-1057. Epub 2015 Feb 17. Cancer Discov. 2015. PMID: 25691096 Free PMC article.

LinkOut - more resources