Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2015 Apr;5(4):353-4.
doi: 10.1158/2159-8290.CD-15-0222.

Targeting Autophagy in BRAF-Mutant Tumors

Andrew Thorburn  1 , Michael J Morgan  2
Affiliations
Comment

Targeting Autophagy in BRAF-Mutant Tumors

Andrew Thorburn et al. Cancer Discov. 2015 Apr.

Abstract

Recent studies have highlighted the opportunity to treat cancer by inhibiting autophagy, but have also raised important caveats with this idea. An article in this issue of Cancer Discovery adds to accumulating evidence suggesting that we should focus our efforts (at least initially) on specific tumors where we are most likely to see beneficial effects.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest. The authors disclose no potential conflicts of interest

Comment on

References

    1. White E. Deconvoluting the context-dependent role for autophagy in cancer. Nature reviews Cancer. 2012;12:401–410. - PMC - PubMed
    1. Thorburn A. Autophagy and its effects: making sense of double-edged swords. PLoS biology. 2014;12:e1001967. - PMC - PubMed
    1. Mehnert JM, Xie X, Koh JY, Price S, White E. Atg7 overcomes senescence and promotes growth of BRAFV600E-driven melanoma. Cancer discovery. 2015 - PMC - PubMed
    1. Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, et al. Autophagy is Required for Glucose Homeostasis and Lung Tumor Maintenance. Cancer Discov. 2014;4:914–927. - PMC - PubMed
    1. Yang A, Rajeshkumar NV, Wang X, Yabuuchi S, Alexander BM, Chu GC, et al. Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations. Cancer Discov. 2014;4:905–913. - PMC - PubMed

Publication types

Substances