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. 2015 Mar 23:8:649-59.
doi: 10.2147/OTT.S76526. eCollection 2015.

Clinical significance of ALDH2 rs671 polymorphism in esophageal cancer: evidence from 31 case-control studies

Tingting Zhao  1 , Chun Wang  1 , Lili Shen  1 , Dongying Gu  1 , Zhi Xu  1 , Xunlei Zhang  2 , Yong Xu  1 , Jinfei Chen  1
Affiliations

Clinical significance of ALDH2 rs671 polymorphism in esophageal cancer: evidence from 31 case-control studies

Tingting Zhao et al. Onco Targets Ther. .

Abstract

Background: Aldehyde dehydrogenase 2 (ALDH2), a critical enzyme for the detoxification of alcohol, is associated with many types of cancers. To verify the relationship of ALDH2 rs671 G>A polymorphism and esophageal cancer (EC), we performed a meta-analysis of a total of 31 published data including 8,510 patients and 16,197 controls.

Methods: The pooled odds ratio (OR) and the 95% confidence interval (CI) were calculated using a fixed or random-effects model. Heterogeneity (PH ), publication bias, and sensitivity analysis were also determined.

Results: Although a protective effort was found in the rs671 homozygote comparison (AA/GG: OR=0.69; 95% CI=0.48-0.98), the heterozygote comparison was apparently associated with the risk of EC, particularly in the Chinese population (

Ag/gg: OR=1.39; 95% CI=1.03-1.87). Alcohol consumption remarkably increased this risk, especially in the AG genotype. Drinking men with the AG genotype appeared to show a higher risk (

Ag/gg: OR=4.39; 95% CI=1.24-6.55) than drinking women.

Conclusion: The present meta-analysis provided advanced information regarding the association of the ALDH2 A>G polymorphism and EC. Taken together, insights from this study suggested an enhanced effect on the development of EC through a genetic-environmental interaction.

Keywords: EC; SNP; aldehyde dehydrogenase-2; esophageal cancer; meta-analysis; single nucleotide polymorphism.

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Figures

Figure 1
Figure 1
Diagram of the relevant literature search and selection procedure.
Figure 2
Figure 2
Begg’s funnel plot of the publication bias test. Notes: (A) GA/GG comparison; (B) GA/GG comparison. Each point represents a separate study for the indicated association. Horizontal line, effect size. Abbreviations: logOR, natural logarithm of the odds ratio; SE, standard error.
Figure 3
Figure 3
Association of the ALDH2 AG genotype and the risk of EC. Notes: We reclassified alcohol-drinking status according to data from the different studies by approximately measuring alcohol intake levels as never-drinkers = no, never, and rare; exdrinkers = stopped drinking alcohol for more than 1 year; light drinkers =1–350 g/week of alcohol; heavy drinkers ≥350 g/week of alcohol. Abbreviations: ID, identifier; OR, odds ratio; CI, confidence interval; ALDH2, aldehyde dehydrogenase 2; EC, esophageal cancer.
Figure 4
Figure 4
Association of the ALDH2 AA genotype with the risk of EC. Notes: Never-drinkers: no, never, and rare. Drinkers: all those who drink alcohol. Abbreviations: ID, identifier; OR, odds ratio; CI, confidence interval; ALDH2, aldehyde dehydrogenase 2; EC, esophageal cancer.
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References

    1. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64(1):9–29. - PubMed
    1. Pharoah PD, Dunning AM, Ponder BA, Easton DF. Association studies for finding cancer-susceptibility genetic variants. Nat Rev Cancer. 2004;4(11):850–860. - PubMed
    1. Baan R, Straif K, Grosse Y, et al. WHO International Agency for Research on Cancer Monograph Working Group Carcinogenicity of alcoholic beverages. Lancet Oncol. 2007;8(4):292–293. - PubMed
    1. Eriksson CJ. The role of acetaldehyde in the actions of alcohol (update 2000) Alcohol Clin Exp Res. 2001;25(5 Suppl ISBRA):15S–32S. - PubMed
    1. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans Alcohol consumption and ethyl carbamate. IARC Monogr Eval Carcinog Risks Hum. 2010;96:3–1383. - PMC - PubMed