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Review
. 2015 May;14(5):329-45.
doi: 10.1038/nrd4433. Epub 2015 Apr 7.

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

John L Wallace  1 , Rui Wang  2
Affiliations
Review

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

John L Wallace et al. Nat Rev Drug Discov. 2015 May.

Abstract

Hydrogen sulfide (H2S) has become recognized as an important signalling molecule throughout the body, contributing to many physiological and pathological processes. In recent years, improved methods for measuring H2S levels and the availability of a wider range of H2S donors and more selective inhibitors of H2S synthesis have helped to more accurately identify the many biological effects of this highly reactive gaseous mediator. Animal studies of several H2S-releasing drugs have demonstrated considerable promise for the safe treatment of a wide range of disorders. Several such drugs are now in clinical trials.

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References

    1. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12679-84 - PubMed
    1. J Pharmacol Exp Ther. 2006 Oct;319(1):447-58 - PubMed
    1. Biochem Biophys Res Commun. 2012 Nov 30;428(4):469-74 - PubMed
    1. PLoS One. 2014 Oct 21;9(10):e110688 - PubMed
    1. Antioxid Redox Signal. 2011 Jul 15;15(2):373-8 - PubMed

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