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. 2015 May 4;51(36):7626-8.
doi: 10.1039/c5cc01309g.

Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids

Franziska Kellner  1 , Fernando Geu-Flores, Nathaniel H Sherden, Stephanie Brown, Emilien Foureau, Vincent Courdavault, Sarah E O'Connor
Affiliations

Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids

Franziska Kellner et al. Chem Commun (Camb). .

Abstract

Here we report the discovery of a cytochrome P450 that is required for the biosynthesis of vindoline, a plant-derived natural product used for semi-synthesis of several anti-cancer drugs. This enzyme catalyzes the formation of an epoxide that can undergo rearrangement to yield the vincamine-eburnamine backbone, thereby providing evidence for the long-standing hypothesis that the aspidosperma- and eburnamine-type alkaloids are biosynthetically related.

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