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Review
. 2015 May 21;125(21):3230-5.
doi: 10.1182/blood-2014-10-567784. Epub 2015 Apr 7.

The role of stem cell transplantation for chronic myelogenous leukemia in the 21st century

A John Barrett  1 , Sawa Ito  1
Affiliations
Review

The role of stem cell transplantation for chronic myelogenous leukemia in the 21st century

A John Barrett et al. Blood. .

Abstract

The introduction of tyrosine kinase inhibitors (TKIs), a treatment of chronic myelogenous leukemia (CML), has largely replaced curative strategies based on allogeneic stem cell transplantation (SCT). Nevertheless, SCT still remains an option for accelerated/blastic-phase and selected chronic-phase CML. Transplant outcomes can be optimized by peritransplant TKIs, conditioning regimen, BCR-ABL monitoring, and relapse management. Controversies exist in transplant timing, pediatric CML, alternative donors, and economics. SCT continues to serve as a platform of "operational cure" for CML with TKIs and immunotherapies.

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