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Review
. 2015 Mar 24:6:41.
doi: 10.3389/fendo.2015.00041. eCollection 2015.

Coupling Signals between the Osteoclast and Osteoblast: How are Messages Transmitted between These Temporary Visitors to the Bone Surface?

Natalie A Sims  1 , T John Martin  1
Affiliations
Review

Coupling Signals between the Osteoclast and Osteoblast: How are Messages Transmitted between These Temporary Visitors to the Bone Surface?

Natalie A Sims et al. Front Endocrinol (Lausanne). .
No abstract available

Keywords: coupling; osteoblast; osteoclast; osteocyte.

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Figures

Figure 1
Figure 1
Possible coupling mechanisms that overcome the time delay between bone resorption and formation. (A) Osteoclast-derived factors (either released from the matrix, secreted from the osteoclast, or expressed on the osteoclast cell membrane) initiate differentiation of very early osteoblast progenitors, with the level of osteoblast activity and numbers of differentiated cells being refined by other factors released by a range of cell types within the BMU. Osteoclast-derived factors may act directly on cells that would transmit further signals (dashed lines) to both osteoblast precursors and mature osteoblasts; these transmitting cells could include (B) osteoblast-lineage cells in the remodeling canopy, (C) reversal cells on the bone surface, and (D) osteocytes. Finally, (E) physical changes brought about by the osteoclast, including the resorptive pit itself, and mechanical strain detected by the osteocyte network, would provide signals required for initiation and completion of the correct level of matrix production by mature osteoblasts on the bone surface. Periods of time required for each step are based on adult human iliac crest biopsies.
See this image and copyright information in PMC

References

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