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. 2015 Apr;28(2):153-5.
doi: 10.3344/kjp.2015.28.2.153. Epub 2015 Apr 1.

Delayed allergic reaction to secondary administrated epidural hyaluronidase

A Reum Park  1 , Woong Mo Kim  1 , Bong Ha Heo  1
Affiliations

Delayed allergic reaction to secondary administrated epidural hyaluronidase

A Reum Park et al. Korean J Pain. 2015 Apr.

Abstract

We are reporting a rare case of a delayed hypersensitivity reaction caused by hyaluronidase allergy following a lumbar transforaminal epidural block. Using an intradermal skin test, we have provided evidence that the systemic allergic reaction resulted from hypersensitivity to hyaluronidase. To our knowledge, this is a rare case of a delayed hypersensitivity reaction to epidural hyaluronidase, comprised of an initial exposure to hyaluronidase with no subsequent allergic response in prior block followed by a subsequent delayed reaction to hyaluronidase during a second epidural block.

Keywords: Allergy; Epidural; Hyaluronidase; Hypersensitivity; Pain; Skin test.

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Figures

Fig. 1
Fig. 1. A positive result was found for hyaluronidase (15 IU/ml) with a persistent wheal.
See this image and copyright information in PMC

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