Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Apr;28(2):153-5.
doi: 10.3344/kjp.2015.28.2.153. Epub 2015 Apr 1.

Delayed allergic reaction to secondary administrated epidural hyaluronidase

A Reum Park  1 , Woong Mo Kim  1 , Bong Ha Heo  1
Affiliations

Delayed allergic reaction to secondary administrated epidural hyaluronidase

A Reum Park et al. Korean J Pain. 2015 Apr.

Abstract

We are reporting a rare case of a delayed hypersensitivity reaction caused by hyaluronidase allergy following a lumbar transforaminal epidural block. Using an intradermal skin test, we have provided evidence that the systemic allergic reaction resulted from hypersensitivity to hyaluronidase. To our knowledge, this is a rare case of a delayed hypersensitivity reaction to epidural hyaluronidase, comprised of an initial exposure to hyaluronidase with no subsequent allergic response in prior block followed by a subsequent delayed reaction to hyaluronidase during a second epidural block.

Keywords: Allergy; Epidural; Hyaluronidase; Hypersensitivity; Pain; Skin test.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1. A positive result was found for hyaluronidase (15 IU/ml) with a persistent wheal.
See this image and copyright information in PMC

References

    1. Delaere L, Zeyen T, Foets B, Van Calster J, Stalmans I. Allergic reaction to hyaluronidase after retrobulbar anaesthesia: a case series and review. Int Ophthalmol. 2009;29:521–528. - PubMed
    1. Szépfalusi Z, Nentwich I, Dobner M, Pillwein K, Urbanek R. IgE-mediated allergic reaction to hyaluronidase in paediatric oncological patients. Eur J Pediatr. 1997;156:199–203. - PubMed
    1. Geurts JW, Kallewaard JW, Richardson J, Groen GJ. Targeted methylprednisolone acetate/hyaluronidase/clonidine injection after diagnostic epiduroscopy for chronic sciatica: a prospective, 1-year follow-up study. Reg Anesth Pain Med. 2002;27:343–352. - PubMed
    1. Kempeneers A, Dralands L, Ceuppens J. Hyaluronidase induced orbital pseudotumor as complication of retrobulbar anesthesia. Bull Soc Belge Ophtalmol. 1992;243:159–166. - PubMed
    1. Kirby B, Butt A, Morrison AM, Beck MH. Type I allergic reaction to hyaluronidase during ophthalmic surgery. Contact Dermatitis. 2001;44:52. - PubMed

LinkOut - more resources