Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Mar 21:14:28.
doi: 10.1186/s12937-015-0017-0.

Association between phosphorus intake and bone health in the NHANES population

Albert W Lee  1 , Susan S Cho
Affiliations

Association between phosphorus intake and bone health in the NHANES population

Albert W Lee et al. Nutr J. .

Abstract

The objective of this study was to estimate the independent associations between intake of phosphorus (P) and bone health parameters such as bone mineral content (BMC) and bone mineral density (BMD). It provides odds ratio (OR) of osteoporosis with quartiles of P intake adjusted for covariates (i.e., age, gender, BMI, and consumption of calcium (Ca), protein, total dairy foods, and vitamin D as well as intakes of supplemental Ca, vitamin D, and multivitamins/minerals). Data came from males and females aged 13-99 years who participated in the 2005-2010 National Health and Nutrition Examination Survey (NHANES). Analyses showed that higher P intake was associated with higher Ca intake, and that dietary Ca:P ratios (0.51-0.62, with a mean of 0.60 for adults) were adequate in all age/gender groups. High intake of P was positively associated with BMC in female teenagers (Q4 vs. Q1: BMC, 30.9 ± 1.1 vs. 29.0 ± 0.5 g, P = 0.001). It was also positively associated with BMC and BMD as well as reduced risk of osteoporosis in adults >20 years of age (Q4 vs. Q1: OR of osteoporosis, 0.55; 95% confidence interval [CI], 0.39- 0.79; P = 0.001; BMC, 37.5 ± 0.4 vs. 36.70 ± 0.3 g, P < 0.01; BMD, 0.986 ± 0.004 vs. 0.966 ± 0.005 g/cm(2), P < 0.05). The data suggest that high intake of P has no adverse effect on bone metabolism in populations with adequate Ca intake, and that it is also associated with positive bone parameters in some age/gender groups.

PubMed Disclaimer

References

    1. World Health Organization (WHO). 2007. WHO Scientific Group on the Assessmalest of Osteoporosis at Primary Health Care Level. Summary Meeting Report. Brussels, Belgium, 5–7 May 2004. Available at: http://www.who.int/chp/topics/Osteoporosis.pdf.
    1. EFSA. EFSA Panel on Dietetic Products, Nutrition and Allergies Scientific opinion on the substantiation of health claims related to calcium and maintenance of normal bone and teeth (ID 2731, 3155, 4311, 4312, 4703), maintenance of normal hair and nails (ID 399, 3155), maintenance of normal blood LDL-cholesterol concentrations (ID 349, 1893), maintenance of normal blood HDL-cholesterol concentrations (ID 349, 1893), reduction in the severity of symptoms related to the premenstrual syndrome (ID 348, 1892). “cell membrane permeability” (ID 363), reduction of tiredness and fatigue (ID 232), contribution to normal psychological functions (ID 233), contribution to maintenance or achievemalest of a normal body weight (ID 228, 229) and regulation of normal cell division and differentiation (ID237) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J. 2010;8:1725. doi: 10.2903/j.efsa.2010.1725. - DOI
    1. Institute of Medicine (IOM) Dietary Reference Intakes for calcium, phosphorus, magnesium, Vitamin D, and fluoride. Washington, D.C: National Academy of Sciences; 2001. pp. 1678–82.
    1. Ka¨rkka¨inen KUM, Lamberg-Allardt CJE. An acute intake of phosphate increases parathyroid hormone secretion and inhibits bone formation in young women. J Bone Miner Res. 1996;11:1905–12. doi: 10.1002/jbmr.5650111211. - DOI - PubMed
    1. Kemi VE, Kärkkäinen MU, Lamberg-Allardt CJ. High phosphorus intakes acutely and negatively affect Ca and bone metabolism in a dose-dependent manner in healthy young females. Br J Nutr. 2006;96:545–52. - PubMed

Publication types

MeSH terms