doi: 10.1039/c5ob00228a.
Concise total synthesis of (±)-aspidospermidine
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- PMID: 25856579
- DOI: 10.1039/c5ob00228a
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Concise total synthesis of (±)-aspidospermidine
Org Biomol Chem.
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Abstract
(±)-Aspidospermidine (1) has been synthesized from the commercially available 2,3-dihydro-1H-carbazol-4(9H)-one 6 in 10 steps with 20% overall yield. The key step of the strategy is a one-pot carbonyl reduction/iminium formation/intramolecular conjugate addition reaction that may be applied for the synthesis of other Aspidosperma alkaloids.
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