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. 2015 May 14;13(18):5255-9.
doi: 10.1039/c5ob00228a.

Concise total synthesis of (±)-aspidospermidine

Haichen Ma  1 , Xingang Xie, Peng Jing, Weiwei Zhang, Xuegong She
Affiliations

Concise total synthesis of (±)-aspidospermidine

Haichen Ma et al. Org Biomol Chem. .

Abstract

(±)-Aspidospermidine (1) has been synthesized from the commercially available 2,3-dihydro-1H-carbazol-4(9H)-one 6 in 10 steps with 20% overall yield. The key step of the strategy is a one-pot carbonyl reduction/iminium formation/intramolecular conjugate addition reaction that may be applied for the synthesis of other Aspidosperma alkaloids.

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