Host autophagy combating S. aureus: α-toxin will be tolerated

doi:10.1016/j.chom.2015.03.010

Comment

. 2015 Apr 8;17(4):419-20.

doi: 10.1016/j.chom.2015.03.010.

Host autophagy combating S. aureus: α-toxin will be tolerated

Michael E Powers¹, Juliane Bubeck Wardenburg²

Affiliations

¹ Department of Microbiology, University of Chicago, Chicago, IL 60637, USA.
² Department of Microbiology, University of Chicago, Chicago, IL 60637, USA; Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA. Electronic address: jbubeckw@peds.bsd.uchicago.edu.

PMID: 25856749
PMCID: PMC4642995
DOI: 10.1016/j.chom.2015.03.010

Comment

Host autophagy combating S. aureus: α-toxin will be tolerated

Michael E Powers et al. Cell Host Microbe. 2015.

. 2015 Apr 8;17(4):419-20.

doi: 10.1016/j.chom.2015.03.010.

Authors

Michael E Powers¹, Juliane Bubeck Wardenburg²

Affiliations

¹ Department of Microbiology, University of Chicago, Chicago, IL 60637, USA.
² Department of Microbiology, University of Chicago, Chicago, IL 60637, USA; Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA. Electronic address: jbubeckw@peds.bsd.uchicago.edu.

PMID: 25856749
PMCID: PMC4642995
DOI: 10.1016/j.chom.2015.03.010

Abstract

Autophagy regulates the degradation of both cellular components and invading intracellular pathogens. In this issue of Cell Host & Microbe, Maurer et al. (2015) reveal that cellular autophagy decreases host sensitivity to Staphylococcus aureus α-toxin via reduced expression of the toxin receptor ADAM10, thus rendering the host tolerant to disease.

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Comment on

Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin.
Maurer K, Reyes-Robles T, Alonzo F 3rd, Durbin J, Torres VJ, Cadwell K. Maurer K, et al. Cell Host Microbe. 2015 Apr 8;17(4):429-40. doi: 10.1016/j.chom.2015.03.001. Epub 2015 Mar 26. Cell Host Microbe. 2015. PMID: 25816775 Free PMC article.

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Cosmosiin Increases ADAM10 Expression via Mechanisms Involving 5'UTR and PI3K Signaling.
Min Z, Tang Y, Hu XT, Zhu BL, Ma YL, Zha JS, Deng XJ, Yan Z, Chen GJ. Min Z, et al. Front Mol Neurosci. 2018 Jun 11;11:198. doi: 10.3389/fnmol.2018.00198. eCollection 2018. Front Mol Neurosci. 2018. PMID: 29942252 Free PMC article.
Interactions between Autophagy and Bacterial Toxins: Targets for Therapy?
Mathieu J. Mathieu J. Toxins (Basel). 2015 Aug 4;7(8):2918-58. doi: 10.3390/toxins7082918. Toxins (Basel). 2015. PMID: 26248079 Free PMC article. Review.

References

1. Becker RE, Berube BJ, Sampedro GR, De-Dent AC, Bubeck Wardenburg J. J Innate Immun. 2014;6:619–631. - PMC - PubMed
1. Bubeck Wardenburg J, Patel RJ, Schneewind O. Infect Immun. 2007;75:1040–1044. - PMC - PubMed
1. Huang J, Brumell JH. Nat Rev Microbiol. 2014;12:101–114. - PMC - PubMed
1. Inoshima I, Inoshima N, Wilke GA, Powers ME, Frank KM, Wang Y, Bubeck Wardenburg J. Nat Med. 2011;17:1310–1314. - PMC - PubMed
1. Marchiando AM, Ramanan D, Ding Y, Gomez LE, Hubbard-Lucey VM, Maurer K, Wang C, Ziel JW, van Rooijen N, Nuñez G, et al. Cell Host Microbe. 2013;14:216–224. - PMC - PubMed

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[1] Becker RE, Berube BJ, Sampedro GR, De-Dent AC, Bubeck Wardenburg J. J Innate Immun. 2014;6:619–631. - PMC - PubMed

[2] Becker RE, Berube BJ, Sampedro GR, De-Dent AC, Bubeck Wardenburg J. J Innate Immun. 2014;6:619–631. - PMC - PubMed

[3] Bubeck Wardenburg J, Patel RJ, Schneewind O. Infect Immun. 2007;75:1040–1044. - PMC - PubMed

[4] Bubeck Wardenburg J, Patel RJ, Schneewind O. Infect Immun. 2007;75:1040–1044. - PMC - PubMed

[5] Huang J, Brumell JH. Nat Rev Microbiol. 2014;12:101–114. - PMC - PubMed

[6] Huang J, Brumell JH. Nat Rev Microbiol. 2014;12:101–114. - PMC - PubMed

[7] Inoshima I, Inoshima N, Wilke GA, Powers ME, Frank KM, Wang Y, Bubeck Wardenburg J. Nat Med. 2011;17:1310–1314. - PMC - PubMed

[8] Inoshima I, Inoshima N, Wilke GA, Powers ME, Frank KM, Wang Y, Bubeck Wardenburg J. Nat Med. 2011;17:1310–1314. - PMC - PubMed

[9] Marchiando AM, Ramanan D, Ding Y, Gomez LE, Hubbard-Lucey VM, Maurer K, Wang C, Ziel JW, van Rooijen N, Nuñez G, et al. Cell Host Microbe. 2013;14:216–224. - PMC - PubMed

[10] Marchiando AM, Ramanan D, Ding Y, Gomez LE, Hubbard-Lucey VM, Maurer K, Wang C, Ziel JW, van Rooijen N, Nuñez G, et al. Cell Host Microbe. 2013;14:216–224. - PMC - PubMed

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Host autophagy combating S. aureus: α-toxin will be tolerated

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Host autophagy combating S. aureus: α-toxin will be tolerated

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