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Review
. 2015 May;16(5):269-80.
doi: 10.1038/nrm3970. Epub 2015 Apr 10.

Multidimensional proteomics for cell biology

Mark Larance  1 , Angus I Lamond  1
Affiliations
Review

Multidimensional proteomics for cell biology

Mark Larance et al. Nat Rev Mol Cell Biol. 2015 May.

Abstract

The proteome is a dynamic system in which each protein has interconnected properties - dimensions - that together contribute to the phenotype of a cell. Measuring these properties has proved challenging owing to their diversity and dynamic nature. Advances in mass spectrometry-based proteomics now enable the measurement of multiple properties for thousands of proteins, including their abundance, isoform expression, turnover rate, subcellular localization, post-translational modifications and interactions. Complementing these experimental developments are new data analysis, integration and visualization tools as well as data-sharing resources. Together, these advances in the multidimensional analysis of the proteome are transforming our understanding of various cellular and physiological processes.

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