Recent advances on anti-HIV vaginal delivery systems development
- PMID: 25858666
- DOI: 10.1016/j.addr.2015.03.015
Recent advances on anti-HIV vaginal delivery systems development
Abstract
A review of the recent outcomes regarding technologies to prevent vaginal transmission of HIV, mainly by using antiretroviral (ARV) drugs formulated as microbicides. An introduction about the HIV transmission mechanisms by the vaginal route is included, together with the recent challenges faced for development of successful microbicide products. The outcomes of clinical evaluations are mentioned, and the different formulation strategies studied to-date, with the requirements, advantages, disadvantages and limitations of each dosage-form type, are presented. Finally, the recent attempts to apply various types of nanotechnologies in order to develop advanced microbicide-products and overcome existing limitations, are discussed.
Keywords: AIDS; Formulation; HIV; Microbicides; Mucosal; Nanotechnology; Transmission; Vaginal.
Copyright © 2015 Elsevier B.V. All rights reserved.
Similar articles
-
Acceptability and preferences for vaginal dosage forms intended for prevention of HIV or HIV and pregnancy.Adv Drug Deliv Rev. 2015 Sep 15;92:146-54. doi: 10.1016/j.addr.2015.02.004. Epub 2015 Feb 19. Adv Drug Deliv Rev. 2015. PMID: 25703190 Review.
-
Polymer-based nanocarriers for vaginal drug delivery.Adv Drug Deliv Rev. 2015 Sep 15;92:53-70. doi: 10.1016/j.addr.2014.12.004. Epub 2014 Dec 27. Adv Drug Deliv Rev. 2015. PMID: 25550217 Review.
-
Special issue on vaginal drug delivery.Adv Drug Deliv Rev. 2015 Sep 15;92:1. doi: 10.1016/j.addr.2015.09.006. Adv Drug Deliv Rev. 2015. PMID: 26452325 No abstract available.
-
Vaginal drug distribution modeling.Adv Drug Deliv Rev. 2015 Sep 15;92:2-13. doi: 10.1016/j.addr.2015.04.017. Epub 2015 Apr 28. Adv Drug Deliv Rev. 2015. PMID: 25933938 Free PMC article. Review.
-
Advances in development, scale-up and manufacturing of microbicide gels, films, and tablets.Antiviral Res. 2010 Dec;88 Suppl 1:S19-29. doi: 10.1016/j.antiviral.2010.09.010. Antiviral Res. 2010. PMID: 21109064 Review.
Cited by
-
Human vaginal fluid contains exosomes that have an inhibitory effect on an early step of the HIV-1 life cycle.AIDS. 2016 Nov 13;30(17):2611-2616. doi: 10.1097/QAD.0000000000001236. AIDS. 2016. PMID: 27536982 Free PMC article.
-
Pharmacokinetics of the Protein Microbicide 5P12-RANTES in Sheep following Single-Dose Vaginal Gel Administration.Antimicrob Agents Chemother. 2017 Sep 22;61(10):e00965-17. doi: 10.1128/AAC.00965-17. Print 2017 Oct. Antimicrob Agents Chemother. 2017. PMID: 28784672 Free PMC article.
-
Emergence of Nanotechnology to Fight HIV Sexual Transmission: The Trip of G2-S16 Polyanionic Carbosilane Dendrimer to Possible Pre-Clinical Trials.Int J Mol Sci. 2020 Dec 10;21(24):9403. doi: 10.3390/ijms21249403. Int J Mol Sci. 2020. PMID: 33321835 Free PMC article. Review.
-
Advanced Solid Formulations For Vulvovaginal Candidiasis.Pharm Res. 2023 Feb;40(2):593-610. doi: 10.1007/s11095-022-03441-5. Epub 2022 Nov 30. Pharm Res. 2023. PMID: 36451068 Review.
-
Mucoadhesive Vaginal Discs based on Cyclodextrin and Surfactants for the Controlled Release of Antiretroviral Drugs to Prevent the Sexual Transmission of HIV.Pharmaceutics. 2020 Apr 2;12(4):321. doi: 10.3390/pharmaceutics12040321. Pharmaceutics. 2020. PMID: 32265431 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
