Mutations in complement C3 from aHUS patients
- PMID: 25858888
- DOI: 10.1182/blood-2015-02-625285
Mutations in complement C3 from aHUS patients
Abstract
In this issue of Blood, Schramm et al demonstrate that the majority of mutations in complement C3 identified in atypical hemolytic uremic syndrome (aHUS) patients cause dysregulation in the alternative pathway of complement.
Comment on
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Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome.Blood. 2015 Apr 9;125(15):2359-69. doi: 10.1182/blood-2014-10-609073. Epub 2015 Jan 21. Blood. 2015. PMID: 25608561 Free PMC article.
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