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Review
. 2015 Mar 25:7:42.
doi: 10.3389/fnagi.2015.00042. eCollection 2015.

Are AD-Typical Regions the Convergence Point of Multiple Pathologies?

Sylvia Villeneuve  1 , Miranka Wirth  1 , Renaud La Joie  1
Affiliations
Review

Are AD-Typical Regions the Convergence Point of Multiple Pathologies?

Sylvia Villeneuve et al. Front Aging Neurosci. .
No abstract available

Keywords: Alzheimer’s disease; aging; amyloid; neurodegeneration; tau; vascular.

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Figures

Figure 1
Figure 1
Regional convergence of different pathologies (and their impact) involved in the clinical expression of late-onset Alzheimer’s disease. (A) Solid lines represent pathologies that are needed to develop the clinical onset of Alzheimer’s disease (AD), while the dotted line represent a pathological factor that is not needed but, if present increases the risk of developing AD. (B) The pattern of brain injury associated with tau, Aβ, and vascular pathologies is represented by a schematic illustration based on current literature (Braak and Braak, ; Whitwell et al., ; Debette et al., ; La Joie et al., ; Villeneuve et al., 2014). (C) White dots represent brain regions where at least two pathologies are converging. These white dots also represent brain regions that are typically found to be atrophied and/or hypometabolic in individuals with AD (Dickerson et al., ; Landau et al., ; Schroeter and Neumann, ; Wirth et al., 2013a), and when atrophied in cognitively normal older adults, they increase the risk of progression to AD (Dickerson et al., 2009).
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