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. 2015 Mar 26:6:61.
doi: 10.3389/fphar.2015.00061. eCollection 2015.

Whole genome sequencing in pharmacogenomics

Theodora Katsila  1 , George P Patrinos  1
Affiliations

Whole genome sequencing in pharmacogenomics

Theodora Katsila et al. Front Pharmacol. .

Abstract

Pharmacogenomics aims to shed light on the role of genes and genomic variants in clinical treatment response. Although, several drug-gene relationships are characterized to date, many challenges still remain toward the application of pharmacogenomics in the clinic; clinical guidelines for pharmacogenomic testing are still in their infancy, whereas the emerging high throughput genotyping technologies produce a tsunami of new findings. Herein, the potential of whole genome sequencing on pharmacogenomics research and clinical application are highlighted.

Keywords: genome-wide association studies; genotype; pesonalized medicine; pharmacogenomics; pharmacogenomics biomarkers; whole genome sequencing.

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References

    1. Altman R. B., Whirl-Carrillo M., Klein T. E. (2013). Challenges in the pharmacogenomic annotation of whole genomes. Clin. Pharmacol. Ther. 94 211–213 10.1038/clpt.2013.111 - DOI - PMC - PubMed
    1. Ardlie K. G., Kruglyak L., Seielstad M. (2002). Patterns of linkage dis- equilibrium in the human genome. Nat. Rev. Genet. 3 299–309 10.1038/nrg777 - DOI - PubMed
    1. Ashley E. A., Butte A. J., Wheeler M. T. (2010). Clinical assessment incorporating a personal genome. Lancet 375 1525–1535 10.1016/S0140-6736(10)60452-7 - DOI - PMC - PubMed
    1. Crews K. R., Hicks J. K., Pui C. H., Relling M. V., Evans W. E. (2012). Pharmacogenomics and individualized medicine: translating science into practice. Clin. Pharmacol. Ther. 92 467–475 10.1038/clpt.2012.120 - DOI - PMC - PubMed
    1. Drögemöller B. I., Wright G. E. B., Niehaus D. J. H., Emsley R. A., Warnich L. (2011). Whole-genome resequencingin pharmacogenomics: moving away from past disparities to globally representative applications. Pharmacogenomics 12 1717–1728 10.2217/pgs.11.119 - DOI - PubMed

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