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. 2014 Feb;7(1):68-70.
doi: 10.1093/ckj/sft148. Epub 2013 Dec 29.

Severe acute tubular necrosis observed subsequent to oxaliplatin administration

Niall Filewod  1 , Mark L Lipman  2
Affiliations

Severe acute tubular necrosis observed subsequent to oxaliplatin administration

Niall Filewod et al. Clin Kidney J. 2014 Feb.

Abstract

A 67-year-old man known for metastatic colon cancer received treatment with oxaliplatin and developed severe acute kidney injury requiring dialysis. Renal biopsy revealed severe acute tubular necrosis. Acute kidney injury is a rare but severe adverse effect of oxaliplatin administration.

Keywords: AKI; ATN; dialysis; oxaliplatin.

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References

    1. Extra JM, Espie M, Calvo F, et al. Phase I study of oxaliplatin in patients with advanced cancer. Cancer Chemother Pharmacol. 1990;25:299–303. doi:10.1007/BF00684890. - DOI - PubMed
    1. Ito I, Ito Y, Mizuno M, et al. A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin. Clin Exp Nephrol. 2012;16:490–494. doi:10.1007/s10157-012-0620-8. - DOI - PubMed
    1. Linch M, Cunningham D, Mingo O, et al. Renal tubular acidosis due to oxaliplatin. Ann Oncol. 2007;18:805–806. doi:10.1093/annonc/mdm080. - DOI - PubMed
    1. Negro A, Grasselli C, Galli P. Oxaliplatin-induced proximal renal tubular acidosis. Intern Emerg Med. 2010;5:267–268. doi:10.1007/s11739-009-0331-7. - DOI - PubMed
    1. Noronha V, Burtness B, Murren J, et al. Oxaliplatin induces a delayed immune-mediated hemolytic anemia: a case report and review of the literature. Clin Colorectal Cancer. 2005;5:283–286. doi:10.3816/CCC.2005.n.041. - DOI - PubMed

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