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. 1979 Apr 15;180(1):51-8.
doi: 10.1042/bj1800051.

Protein synthesis in muscles from normal and dystrophic hamsters

M Saleem, D M Nicholls

Protein synthesis in muscles from normal and dystrophic hamsters

M Saleem et al. Biochem J. .

Abstract

Homogenates of hindleg muscle were obtained from control and dystrophic male hamsters, 30 and 190 days of age, and were used to prepare the postmicrosomal pH5-supernatant fraction. The activity of this fraction in the incorporation of [14C]phenylalanyl-tRNA into peptides was increased in the dystrophic-muscle preparations. No such increase was found in brain or liver preparations from dystrophic hamsters. The increased capacity for aminoacyl-tRNA binding that was observed in preparations from dystrophic animals is discussed.

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