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. 2015:2015:486974.
doi: 10.1155/2015/486974. Epub 2015 Mar 16.

Association between Helicobacter pylori Infection and Chronic Urticaria: A Meta-Analysis

Huiyuan Gu  1 , Lin Li  1 , Min Gu  2 , Guoxin Zhang  1
Affiliations

Association between Helicobacter pylori Infection and Chronic Urticaria: A Meta-Analysis

Huiyuan Gu et al. Gastroenterol Res Pract. 2015.

Abstract

Background. Some studies have shown the possible involvement of Helicobacter pylori (H. pylori) infection in chronic urticaria, but the relationship remains controversial. The aim of this meta-analysis was to quantitatively assess the association between H. pylori infection and chronic urticaria. Methods. Observational studies comparing the prevalence of H. pylori infection in patients with chronic urticaria and control subjects were identified through a systematic search in MEDLINE and EMBASE up to July 2014. H. pylori infection was confirmed by serological or nonserological tests. For subgroup analyses, studies were separated by region, publication year, and H. pylori detection method to screen the potential factors resulting in heterogeneity. Results. 16 studies involving 965 CU cases and 1235 controls were included. Overall, the prevalence of H. pylori infection was higher in urticarial patients than in controls (OR = 1.66; 95% CI: 1.12-2.45; P = 0.01). This result persisted in subanalysis of nine high-quality studies (OR = 1.36; 95% CI: 1.03-1.80; P = 0.03). Subgroup analysis showed that detection method of H. pylori is also a potential influential factor for the overall results. Conclusions. Our present meta-analysis suggests that H. pylori infection is significantly, though weakly, associated with an increased risk of chronic urticaria.

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Figures

Figure 1
Figure 1
The flow diagram of the literature searches.
Figure 2
Figure 2
Meta-analysis for the association between H. pylori infection and chronic urticaria.
Figure 3
Figure 3
Funnel plot analysis.
Figure 4
Figure 4
Meta-analysis of nine high-quality studies for the association of H. pylori infection with chronic urticaria.
See this image and copyright information in PMC

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