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. 2015 Mar;3(4):51.
doi: 10.3978/j.issn.2305-5839.2015.02.05.

Risk of coronary artery disease in patients with ankylosing spondylitis: a systematic review and meta-analysis

Patompong Ungprasert  1 , Narat Srivali  1 , Wonngarm Kittanamongkolchai  1
Affiliations

Risk of coronary artery disease in patients with ankylosing spondylitis: a systematic review and meta-analysis

Patompong Ungprasert et al. Ann Transl Med. 2015 Mar.

Abstract

Objective: To investigate the association between coronary artery disease (CAD) and ankylosing spondylitis (AS).

Methods: We conducted a systematic review and meta-analysis of observational studies that reported relative risks, hazard ratios, standardized prevalence ratio or standardized incidence ratios with 95% confidence comparing CAD risk in patients with AS versus non-AS controls. Pooled risk ratios and 95% confidence intervals (CIs) were calculated using a random-effect, generic inverse variance of DerSimonian and Laird.

Results: Out of 229 potentially relevant articles, ten studies (five retrospective cohort studies and five cross-sectional studies) were identified and included in our data analysis. The overall pooled risk ratio of CAD in patients with AS was 1.41 (95% CI: 1.29-1.54). The pooled risk ratios for cross-sectional and cohort studies were 2.08 (95% CI: 1.28-3.40) and 1.36 (95% CI: 1.31-1.41), respectively. The statistical heterogeneity of this meta-analysis was moderate with an I(2) of 56%.

Conclusions: Our study demonstrated a statistically significant increased CAD risk among patients with AS with 41% excess risk.

Keywords: Meta-analysis; ankylosing spondylitis (AS); epidemiology; venous thromboembolism.

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Figures

Figure 1
Figure 1
Outline of our search methodology. AS, ankylosing spondylitis.
Figure 2
Figure 2
Forest plot of all included studies.
Figure 3
Figure 3
Funnel plot of all included studies. RR, relative risk.
See this image and copyright information in PMC

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